2016ABSTRACTRecent preclinical studies revealed the eff i cacy of combined use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib in breast and prostate cancers. The current study investigated the effect of such drug combination on ovarian cancer. Here we showed that combined inhibition of PI3K an...
A two-pronged strategy combining the PARP inhibitor olaparib and the PI3K inhibitor BKM120 proved to be a safe and clinically beneficial regimen for women with triple-negative breast cancer and for patients with high-grade serous ovarian cancer.
Matulonis U A,Wulf G M,Barry W T,et al.Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly(ADP ribose)polymerase(PARP)inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer[J].Ann Oncol,2017,28(3):512...
evolved considerably, and two targeted approaches were recently approved: the anti-PD-L1 inhibitor atezolizumab in combination with nab-paclitaxel in PD-L1-positive triple-negative breast cancer [35], and the PARP inhibitors olaparib or talazoparib for germline BRCA1/BRCA2 mutation carriers [36, ...
碳锂AR,99.5%Anti-LDL/FITC 荧光素标记低密度脂蛋白抗体IgG鸡多聚ADP核糖聚合酶4(PARP4)酶联免疫吸附测定试剂盒 碳锂ACS, ≥99.0%Anti-LDL-R/FITC 荧光素标记低密度脂蛋白受体抗体IgG鸡早老素2(PS2)酶联免疫吸附测定试剂盒 碳锂SPAnti-Leptin/FITC 荧光素标记瘦素抗体IgG鸡胞浆蛋白1(STMN1)酶联免疫吸附测...
et al. PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov 2(11), 1036–47 (2012). Article CAS Google Scholar Zheng, Y. et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in ...
Matulonis U A,Wulf G M,Barry W T,et al.Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly(ADP ribose)polymerase(PARP)inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer[J].Ann Oncol,2017,28(3):512-518....
et al. PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov 2(11), 1036–47 (2012). 31. Zheng, Y. et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows ...