We report on a BK virus-associated nephropathy in a 28-year-old man. His symptoms occurred 5 years after he had received a kidney transplantation. He was treated with tacrolimus, azathioprine, and prednisolone. The progress of the disease was monitored by quantitative real-time polymerase chain ...
制可以进一步发展成为BK 病毒相关性肾病(BKvirusas— sociatednephropathy,BKVAN),此类疾病患者中6O%～ 7O%会发生远期的移植肾失功,所以越来越受到人们的广 泛关注. 1BK 病毒的生物学特性BK 病毒(BKV)是乳头多瘤空 泡病毒科的多瘤病毒的一个亚群,是由5kD 碱基对组成的 环状双股DNA 分子,直径为40...
All patients had urinary symptoms, and urine was tested for BK virus replication; 33 patients were positive for BK virus (cases), and 44 were negative (controls). In BK virus cases, the median time to first positive test was 75 days (range, 2-511). BK virus cases had lower CD4 T-...
umbellatus prevented early renal injury in a rat model of nephropathy [23] and may play a central role in the effect exerted by choreito. Pollakisuria was ameliorated in 93% of patients who received choreito for lower urinary tract symptoms in an open-label, single-arm study of 30 ...
virus; detection;diagnosis BKvirus-associatednephropathy(BKVAN)isa rare but serious complication after renal transplantation.[~-s] It has unapparent clinical symptoms andismainly the declineofrenal functionaftertransplantation.Theobjectiveofour precentstudyistoinvestigatetheclinicaldiagnosis 0fBKVAN. MEl’HUD...
The presence of BK virus into urine samples allowed us to make the differential diagnosis between hemorrhagic cystitis due to Endoxan administration and viral infection. Because of absence of viremia, no specific treatment was performed; the symptoms regressed spontaneously after ten days. A new ...
oxidative stress plays an important role in the development of diabetic nephropathy, and a variety of antioxidants can delay the development of DN. Resveratrol can protect against oxidative stress, thereby improving the symptoms of early DN. Resveratrol has obvious anti-oxidative stress effect, can av...
BK Virusencephalitisend‐stage renal diseasehematopoietic stem cell transplantnephropathyBK virus encephalitis after HSCT is uncommon. Several reports of native kidney BKVN in patients with HSCT, hematologic malignancies, human immunodeficiency virus infection, and non‐renal solid organ transplantation have ...
Polyomavirus BKPyV BK virus Human Urothelial cells Renal tubular epithelial cells Replication Hemorrhagic cystitis Nephropathy Transplantation Introduction The human polyomavirus BK (BKPyV) was first isolated from the urine of a renal transplant patient with ureteric stenosis, shedding cytopathically altered ...
Reactivation of human polyomavirus BK (BKV) may cause polyomavirus-associated nephropathy or polyomavirus-associated hemorrhagic cystitis in renal- or bone marrow-transplant patients, respectively. Lack of treatment options has led to exploration of fluoroquinolones that inhibit topoisomerase II and IV in ...