Therefore, mechanistically understanding the engagement of HIF2α with HIF1β and the impact that this has on immune checkpoint interactions is key to understanding appropriate patient selection for therapeutic modalities. Accurate patient stratification remains a key factor for optimising both HIF2α ...
BJC Reports volume 2, Article number: 86 (2024) Cite this article 549 Accesses Metrics details Abstract Background It is difficult for clinicians to make predictions for cancer progression or outcomes based on AJCC staging for individual patients. Models individualising risk prediction for clinical ...
In contrast, there are reports that GADD34 expression has negative effects on pro-inflammatory cytokines. Li et al (2008) showed that CUEDC2 suppressed the activation of IKK through recruitment of GADD34/PP1 and downregulated NFκB signalling that in turn suppressed pro-inflammatory cytokine ...
In addition to its involvement in chromosome condensation (Yang-yen et al., 1988; Giancotti et al., 1989), recent reports suggested another possible role of HMG-I(Y) as a transcription regulatory factor (Fashena et al., 1992; Skalnik et al., 1993). Moreover, the cell cycle-dependent ...
The false negative reports (MRI 2, Doppler 4 and 7) overlapped so that every reacrrence was detected by at least one modality. i.e. 100%! when using both MRI and Doppler uhrasound. Condusions: Both ultrasound and MRI detect the neovascuature of rectrrent breast cancer, with MRI being...
Firstly, sample size and power calculations should always be carried out before the investigation commences, with reports stating how and why they chose that number of subjects to study. Secondly, there is little value in a post hoc calculation which takes the form of, for example, 'we ...
The literature reports a mixed role for ethnicity and socioeconomic background in cancer survival (Parikh-Patel et al, 2006;Moles et al, 2007,Jack et al, 2009,National Cancer Intelligence Network, 2009,van Laar et al, 2012,Ortiz-Ortiz et al, 2014). Ethnic differences in 1- and 3-year ...
Cell-line misidentification and contamination with microorganisms, such as mycoplasma, together with instability, both genetic and phenotypic, are among the problems that continue to affect cell culture. Many of these problems are avoidable with the necessary foresight, and these Guidelines have been pre...