Therefore, mechanistically understanding the engagement of HIF2α with HIF1β and the impact that this has on immune checkpoint interactions is key to understanding appropriate patient selection for therapeutic modalities. Accurate patient stratification remains a key factor for optimising both HIF2α ...
In addition to its involvement in chromosome condensation (Yang-yen et al., 1988; Giancotti et al., 1989), recent reports suggested another possible role of HMG-I(Y) as a transcription regulatory factor (Fashena et al., 1992; Skalnik et al., 1993). Moreover, the cell cycle-dependent ...
Within a UHC system it is clear that a centralised database for annotation and curation of reports is vitally important. Such a system allows finite resources to be used economically including information technology infrastructure and bioinformatics as well as molecular pathology expertise. Furthermore, ...
In a literature survey (Schumacher et al., 1991) coverng Cancer and the Journal of Clinical Oncology over the 5 year period from 1985 to 1989, we found 73 such papers, of which 45 (62%) were reports of clnical trials claiming to have included QoL as an end-point of interest. ...
The false negative reports (MRI 2, Doppler 4 and 7) overlapped so that every reacrrence was detected by at least one modality. i.e. 100%! when using both MRI and Doppler uhrasound. Condusions: Both ultrasound and MRI detect the neovascuature of rectrrent breast cancer, with MRI being...
, 2014). Since bothSTC2andSLCO3A1are thought to have oncogenic roles in cancer they were considered inappropriate for further investigation in our study. On the other hand, decreased expression ofCRBP1or hypermethylation of theCRBP1promoter have been reported in multiple cancers in several reports...
Cell-line misidentification and contamination with microorganisms, such as mycoplasma, together with instability, both genetic and phenotypic, are among the problems that continue to affect cell culture. Many of these problems are avoidable with the necessary foresight, and these Guidelines have been pre...
The literature reports a mixed role for ethnicity and socioeconomic background in cancer survival (Parikh-Patel et al, 2006;Moles et al, 2007,Jack et al, 2009,National Cancer Intelligence Network, 2009,van Laar et al, 2012,Ortiz-Ortiz et al, 2014). Ethnic differences in 1- and 3-year ...
Firstly, sample size and power calculations should always be carried out before the investigation commences, with reports stating how and why they chose that number of subjects to study. Secondly, there is little value in a post hoc calculation which takes the form of, for example, 'we ...
. Of the eight thromboembolic events reported in the current study, none were grade >3 and only one was considered to be possibly related to necitumumab. There were no reports of cardiac ischaemia. Of note, the incidence of grade⩾3 asthenia (27.3%) was somewhat higher than generally ...