The thymoma AB cell line, IU-TAB 1, was tested with increasing log-doses of various PI3K and dual PI3K/mTOR inhibitors currently in phase 2 or 3 clinical trial. Cells were treated for 72 h. The y axis represents percent change in cell viability. The dual PI3K/mTOR inhibitors, PF-046...
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The intention to treat analysis included the 74 randomised patients. At the time of analysis, 34 out of 36 patients in the CAP-CRT arm and 35 out of 38 in the GEM-CRT arm had died. The surviving five patients had been followed up for a median of 12.2 months (IQR: 7.5–41.9).Figure...
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Intrahepatic cholangiocarcinoma (ICC) is a rapidly progressing malignancy; only a minority of the tumours can be resected and the palliative regimens have shown limited success. The aim of this study was to assess overall survival (OS), tumour response a