Genetic loss or pharmacological inhibition of Menin unexpectedly phenocopies the effects of polycomb disruption, resulting in derepression of bivalent genes in both cancer cells and pluripotent stem cells. While Menin and KMT2A/B contribute to H3K4me3 at active genes, a separate Menin-independent ...
Bivalent genes have lower H3K4me3 level in CebpaΔ/Δ HSPCs.Marie, S. HasemannFelicia, K. B. LauridsenJohannes, WaageJanus, S. JakobsenAnneKatrine, FrankMikkel, B. SchusterNicolas, RapinFrederik, O. BaggerPhilipp, S. HoppeTimm, Schroeder...
H3K4me3 and H3K27me3 of each tissue-specific bivalent genes at promoter CGIs and their shores in hESCs and lung. Lung: tissue-specific bivalent genes of lung; Liver: tissue-specific bivalent genes of liver; Pancreas: tissue-specific bivalent genes of pancreas; Spleen:...
Although the H3K27me3 signal was reduced at bivalent promoters, only a subset of bivalent genes showed a significant increase (fold-change cut-off of 2) in mutant mESCs. Bivalent genes upregulated in K27A and shared between the mutants (n = 323) were enriched with typical developmental...
Thousands of mammalian promoters are defined by co-enrichment of the histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus termed bivalent. It was previously observed that bivalent genes in human ES cells (hESC) are frequ
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity. Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccin...
Study on virulence regulatory genes in vibrio cholerae and a bivalent oral candidate vaccine of leishmania donovani and virbrio cholerae . 霍乱弧菌毒力表达调控基因及霍乱、黑热病双价口服活疫苗候选株的研究。 Bivalent inactivated vaccines to infectious coryza . 鸡传染性鼻炎灭活疫苗。 Haemorrhagicfever wit...
Bivalent genes, of which promoters are marked by both H3K4me3 (trimethylation of histone H3 on lysine 4) and H3K27me3 (trimethylation of histone H3 on lysine 27), play critical roles in development and tumorigenesis. Monomethylation on lysine 4 of histone H3 (H3K4me1) is commonly associated...
The gene.selection parameter here does not refer to genes, but the imported genomic regions. We used deepTools (version 3.2.1)86 to visualize the ChIP-seq signal around TSS regions. We used the following parameters for the computeMatrix reference-point subcommand: -b 5000 -a 5000 –binSize ...
whereas inactive or poised genes may lack RNAP or may bind Ser 5-phosphorylated RNAP at promoter proximal regions. Recent studies have demonstrated that silent developmental regulator genes have an unusual histone modification profile in ES cells, being simultaneously marked with Polycomb repressor-media...