The invention relates to novel bis-indole derivatives of the general formula (I) ##STR1## wherein R 1 stands for a hydrogen atom or an acetyl group; R 2 stands for a hydrogen atom; R 3 means an ethyl group of 伪-position; or R 2 and R 3 together represent an oxygen bridge; R...
BIS-INDOLE DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMThe invention is concerned with bis-indole derivatives of the general formuladoi:EP0205169 A2SZANTAY, CSABA, DR.SZABO, LAJOS, DR.HONTY, KATALIN, DR....
Bis-indolinone derivatives having either 2,6-disubstituted pyridine core (1a and 1b) or 1,10-disubstituted phenanthroline core (2a and 2b), already known to have antitumor activity, have been tested as potential G-quadruplex binders. Compounds 2a and 2b are able to selectively stabilize G-qua...
公开/公告号: AU4117800A 公开/公告日期: 2000-11-14 申请(专利权)人: GERHARD EISENBRAND 发明人: G Eisenbrand 摘要: The present invention relates to novel indigoid binsindole derivatives which can be used for the manufacture of a medicament for the treatment of solid cancers.收藏...
The present invention relates to the use of indigoid bisindole derivatives for the manufacture of a medicament for inhibiting cyclin dependent kinases, particularly CDK 1, CDK 2, CDK 4 and CDK 5, more particularly ATP:Proteinphosphotrans... ...
The present invention relates to the use of indigoid bisindole derivatives for the manufacture of a medicament for inhibiting cyclin dependent kinases, particularly CDK 1, CDK 2, CDK 4 and CDK 5, more particularly ATP:Proteinphosphotrans... ...
The present invention relates to the use of indigoid bisindole derivatives for the manufacture of a medicament for inhibiting cyclin dependent kinases, particularly CDK 1, CDK 2, CDK 4 and CDK 5, more particularly ATP:Proteinphosphotrans... EISENBRAND Gerhard,MARKO Doris,TANG Weici,... - WO...
Synthesis of Some New Bisindole Derivatives and Their Biological Activity DOI: 10.4236/ijoc.2016.64019, PP. 187-191 Amal S. Yanni Keywords: Synthesis, Bisindoletetrones, Cycloaddition, Antimicrobial Activity Full-Text Cite this paper Add to My Lib Abstract: Pyrrolidines are well known for th...
4. Conclusions In summary, we have successfully developed a facile, economical, and environmentally friendly method for the construction of highly functionalized 3,71-bisindole derivatives via a Michael addition/cyclocondensation reaction. This allowed for the rapid construction of a novel library of ...
This procedure allows the synthesis of bis(indole) derivatives in good to high yields at 90掳C under silent and ultrasound irradiation conditions. Short reaction times and high yields of desired products are the main advantages of the presented procedure. This reaction catalyzed by 12-tungsto...