本研究通过m5C bis-seq分析,证实了NSUN2在胃癌中表达上调并与不良预后相关,并通过测定了m5C在GC mRNA中的分布,发现m5C修饰的基因主要参与了多种癌症相关的信号通路,SUMO化修饰-NSUN2-m5C轴可能是胃癌和泛癌治疗的一个新的诊断和治疗靶点(图7 )。 图7 SUMO-2/3-NSUN2-m5C修饰在胃癌中的功能景观模型 云序生...
BisSeq integrates data visualization methods to help researchers assess the performance of sequencing read aligners after bisulfite conversion of cytosine's to thymidines. Currently BisSeq supports simulation against single genome. We demonstrate BisSeq's value by using Bismark to map simulated ...
Bisulfite modification of DNA is the most commonly used, "gold standard" method for DNA methylation studies providing single nucleotide resolution. This technology is based on the chemical conversion of unmethylated cytosine to uracil. Methylated cytosines are protected from this conversion allowing to ...
Segmentation of Bis-seq dataLukas BurgerDimos Gaidatzis
本研究通过m5C MeRIP-seq、RNA-seq、m5C Bis-seq等多种技术的联合分析,发现在病毒感染过程中,内源性NSUN2的表达水平降低,因此IRF3 mRNA的m5 C修饰水平降低,但稳定性增加。因此,IRF3的表达水平提高,允许更强的干扰素反应和有效的消除病毒。这种重要的宿主抗病毒策略来调节干扰素反应的进化表明,NSUN2介导的m5 C修饰...
Bis is an optimal transport-based autoencoder model that can capture the intricate distribution of scRNA-seq data while addressing the characteristic sparsity by regularizing the cellular embedding space. After that, we propose a transcriptional expression consistency module that leverages bulk RNA-seq ...
180+ Java applications for analyzing next generation sequencing data from ChIPSeq, RNASeq, BisSeq, DNASeq, variant annotation/ filtering, alignment/VCF QC, capture array design, IGV/ DAS2/IGB/UCSC file manipulation, etc. Both GUI and cmd line interfaces....
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