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privileged structures include the conformational constraint, which has been linked to their greater stability and conformational rigidity and, therefore, higher resistance to protease degradation than acyclic counterparts, as well as their ability to cross the intestinal barrier and the blood–brain barrier...
Infected untreated controls were used for each experiment. Mice were considered cured if surviving more than 30 days beyond death of the last control without parasites in tail vein blood smears. Mean survival (in days) of animals dying of trypanosomiasis is exclusive of cured animals. b ...