Birinapant(Synonyms: 比瑞那帕; TL32711)纯度: 99.70% Birinapant (TL32711) 是一种二价 Smac 模拟物,是XIAP和cIAP1的强效拮抗剂,Kd值分别为 45 nM 和小于 1 nM。Birinapant (TL32711) 诱导完整细胞中 cIAP1 和 cIAP2 的自身泛素化和蛋白酶体降解,从而形成 RIPK1: caspase-8 复合物,caspase-8 活化和...
Obatoclax (developed by Gemin X) is an investigational drug with BCl-2 inhibitory activity. The drug has shown effectiveness in various cancerous conditions including leukemia, lymphoma, small cell lung cancer, non-Hodgkin's lymphoma, multiple myeloma, myelofibrosis and mastocystosis [74-77]. It...
The efficacy of birinapant in combination with carboplatin should be tested in high-grade serous carcinoma patients in a clinical trial.#Carboplatin efficacy can be restored by administering it with birinapant, a drug combination that targets platinum-resistant cancer cells. Platinum-based ...
NCI Drug Dictionarybirinapant SAFETY Risk and Safety Statements Symbol(GHS) GHS07 Signal wordWarning Hazard statementsH302-H315-H319-H335 Precautionary statementsP280-P305+P351+P338 HS Code29339900 Birinapant priceMore Price(16) ManufacturerProduct numberProduct descriptionCAS numberPackagingPriceUpdatedBuy...
Abstract 3333: Birinapant, a novel bivalent Smac mimetic drug, is superior to monovalent Smac mimetics in inhibition of NF-kB by targeting TRAF2-bound cIAP1 and cIAP2. A variety of Smac-mimetic drugs have been developed to target the inhibitor of apoptosis (IAP) proteins including X chromosome...
With the exception of CMS4, these CMS subtypes can be accurately represented by colon cancer cell lines making them a suitable platform to evaluate drug efficacy15. Resistance to chemotherapy often results from defective apoptosis pathways16,17. Inhibitor of apoptosis proteins (IAPs) are important ...
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drug birinapant. Progression free and OS would be assessed and compared with historic controls. The validity of two biomarker assays, western blot and IHC, aimed at measuring levels and percentage of cIAP positive cells would be correlated with response to co-therapy.bPatients with platinum-...
Drug deliveryPaclitaxelpH-sensitiveA novel triblock amphiphilic copolymer (PAL-PEG-Birinapant) was designed and synthesized as a dual-functional micellar carrier utilizing birinapant (an inhibitor of inhibitor-of-apoptosis proteins) as a pH-sensitive segment and inhibitor-of-apoptosis proteins-targeting ...
Drug deliveryPaclitaxelpH-sensitiveA novel triblock amphiphilic copolymer (PAL-PEG-Birinapant) was designed and synthesized as a dual-functional micellar carrier utilizing birinapant (an inhibitor of inhibitor-of-apoptosis proteins) as a pH-sensitive segment and inhibitor-of-apoptosis proteins-targeting ...