I have very little family support as they do not understand what I am going through and I only feel like a burden trying to explain my need to at least be checked on if I am not answering my phone to see if I am all right (I live alone). I feel for all they know, I could ...
preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big data and advances in the ability to analyze these data. The impact of big data on the routine treatment of bipolar disorder today and in the near future is discussed, with ex...
First, ADD3 is a member of a family of cytoskeletal proteins responsible for capping the growing end of actin filaments and promoting the binding of spectrin to actin in the brain and elsewhere. Recently, adducins have been shown to form ladder-like structures in axons similar to those ...
a set of genes belonging to the immunoglobulin heavy and light chains variable region were found to be significantly upregulated in lithium NRs as compared to LRs in the joint datasets. Increased expression of the immunoglobulin family genes specifically in lithium NRs entails the deregulation of ...
Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell 2004; 119: 257–272. 82 Linke S, Hampton-Smith RJ, Peet DJ. Characterization of ankyrin repeat-containing proteins as substrates of the ...
This study provides additional evidence in support of this treatment, with statistically significant data that demonstrate the success of this technique. Methods: In this multicenter, randomized, prospective, double-blinded study with crossover, 17 patients were divided into two groups, with eight ...
In particular, our two-stage strategy found association in both our combined case/control analysis and the family-based analysis on 1q21.2 (closest gene: sphingosine-1-phosphate receptor 1 gene, S1PR1) and on 1q24.1 near the gene TMCO1, and at CSMD1 on 8p23.2, supporting several previous...
Healthy controls were additionally interviewed with the Family Interview for Genetic Studies (FIGS) [27] in order to confirm the absence of a family history of psychotic or bipolar disorder. The initial sample consisted of 81 patients and 61 healthy control subjects. Three patients were excluded ...
The three combined molecular analysis runs for the family Siboglinidae converged on the same tree topology and near identical posterior probability values (maximum variation of 4 %). The 50 % majority rule consensus tree (Fig. 7) indicated overall strong branch support for the monophyly of the...
Family and twin studies have consistently reported high heritability (B0.80) for both disorders4, yet only a modest portion of the genetic variance of either disorder has been explained at the molecular level. The historical distinction between schizophrenia and bipolar disorder, which was based on ...