Mean illness duration was 18.6 years; current depressive episode duration was 18.0 weeks. Prospective 28-item HDRS, Young Mania Rating Scale (YMRS) and Clinical Global Impression – Severity (CGI-S) ratings were obtained. Results: Overall, HDRS ratings decreased 53% from 32.5 ±...
Here, we hypothesize that structure connectivity constrains functional connectivity, and structural–functional coupling is a more sensitive biomarker to detect subtle brain abnormalities than any single modality in BD patients with a current major depressive episode who had attempted suicide. By ...
Decreased AD has previously been reported in first-episode treatment-naïve UD patients, but in left rather than right SLF36. The lack of between-group difference in RD with reduced axial diffusivity suggested that impaired axonal integrity, instead of myelin loss, explained the reduction of MD,...
Perugi G, Micheli C, Akiskal HS, Madaro D, Socci C, Quilici C, Musetti L. Polarity of the first episode, clinical characteristics, and course of manic depressive illness: a systematic retrospective investigation of 320 bipolar I patients. Compr Psychiatry 2000;41:13–18. ArticleCASPubMedGoogl...
Bipolar disorderis amental illness, specifically one of the affective (mood) disorders. It is characterized by severe mood swings, at least one episode of maniaand may include repeated episodes ofdepression. This illness afflicts more than 1% of adults in the United States, up to as many as...
Sometimes you will feel manic and sometimes you will feel depressed. Episodes of mania or depression may last 1 to 2 weeks or longer. You can have mixed symptoms of mania and depression as part of the same episode. This is called a mixed bipolar state....
Hypomania Manic episode Mania Mild Mania with psychosis Moderate Severe Severe with psychosis Bipolar affective disorder Bipolar I and bipolar II disorders Currently hypomanic Current (or most recent episode) Currently manic Hypomanic Currently depressed Manic* Currently mixed Depressed In remission Mi...
Bipolar disorder is a lifelong illness characterized by severe mood swings. People with bipolar can experience periods of elevated mood and depressed mood.
These disorders include: bipolar disorder type I (depressive and manic episodes: this disorder can be diagnosed on the basis of one manic episode); bipolar disorder type II (depressive and hypomanic episodes); cyclothymic disorder (hypomanic and depressive symptoms that do not meet criteria for ...
Current practices for forming bipolar groups, however, limit further inquiry in this direction. Major Depressive Disorder (MDD), for example, shows substantially larger effect sizes when participants are undergoing a current unipolar depressive episode than when they are euthymic or sampled from the gen...