Positive WB detected in HepG2 cells, HeLa cells, A549 cells, MCF-7 cells, Jurkat cells, HSCT6 cells, HSC-T6 cells, PC-12 cells, NIH/3T3 cells, SP2/0 cell, 4T1 cells Positive IP detected in SGC-7901 cells Positive IHC detected in human liver cancer tissue, human colon cancer tissue...
人热休克蛋白70基因的克隆,原核表达,纯化和鉴定 一些热休克蛋白己经成为免疫抑制药的靶标,如:一种强效兔疫抑制 剂脱氧精肌菌素,显示出明确的与HSC70结合活性.近年来,人们研究发 现,当一些多肽抗原与HSP70非... 余厚友 - 《第四军医大学学报》 被引量: 12发表: 2002年 大肠癌腹腔微转移的研究 腹腔内的...
Structural basis of interdomain communication in the Hsc70 chaperone. Mol. Cell 20, 513–524 (2005). Article CAS PubMed PubMed Central Google Scholar Strub, A., Zufall, N. & Voos, W. The putative helical lid of the Hsp70 peptide-binding domain is required for efficient preprotein ...
(E) Upregulation of Hsc70.3WT or Hsc70.3K97S had no effect of the total protein levels of TDP-43. Protein isolated from ~ 5 to 10 male heads immunoblotted for TDP-43 and Tubulin. Protein levels were quantified from 3 independent biological repeats. Data is presented as Mean ±...
Androgen induced a significant increase in the percentage of ESCs and embryoid bodies with the intranuclear and juxtanuclear AR inclusions, which were colocalized with the E3 ubiquitin ligase, C terminus of Hsc70-interacting protein. Caspase-3 activity corresponded with AR expression, was enhanced in...
Comparison of the ATPase cycle of BiP with DnaK and Hsc70 In this study, we determined the kinetic constants of ATP binding and hydrolysis by BiP. This allows us to describe the complete ATPase cycle of BiP. As shown in Figure 5, BiP binds ATP with an KD of 1.1 μM. The observed ra...
Alternatively, BiP might be converted into a pro-ERAD factor, similar to the cytosolic Hsc70-interacting protein, which converts Hsc70 from a folding protein to a degradation factor in the ERAD of cystic fibrosis transmembrane conductance regulator (94). There is also the attractive model that ...
Hsc70 or HSPA8 (constitutive) and Hsp70 or HSPA1 (stress-inducible) are both present in the cytosol/nucleus, mortalin or HSPA9 is localized in the mitochondrial matrix, and 78-kDa glucose-regulated protein (GRP78), binding immunoglobulin protein (BIP), or HSPA5 is present in the ER lumen...
The High Content Screening (HSC) analysis performed in this research showed that TPHE caused MMP loss and subsequent relocalization of cytochrome c from mitochondria to the cytosol. The leakage of pro-apoptotic proteins such as cytochrome c, the serine protease HtrA2/Omi and Smac/DIABLO is ...
现15.8L水司令饮用山泉水3桶套餐,抖音团购23.4元,水好喝健康,快点击左下角。#水是生命之源 #喝天然矿泉水的好处 #矿泉水品牌推荐 #饮用水大桶装 #周末时光 柳江买水就来Rowte水司令超市。现15.8L水司令饮用山泉水3桶套餐,抖音团购23.4元,水好喝健康,快点击左下角。#水是生命之源 #喝天然矿泉水的好处 #...