Most of the published research on biotin interference covers hormone tests, such asparathyroid hormone (PTH),thyroid stimulating hormone (TSH),T4andT3tests, as well as tests for troponin. However, because biotin is used in so many immunoassays, scientists say it could interfere with many others....
Repeat testing showed high fT3, fT4, and low TSH and -ve TSH receptor antibody. On enquiring about any medicinal history, she admitted taking a supplement for the last 3 months for her hair fall, which had 500 mcg biotin in it. TFTs were repeated after stopping the suppl...
Therefore, this study was designed to assess the association of short-term biotin ingestion for 7 days with performance of assays that measure 11 hormone and nonhormone analytes: thyroid-stimulating hormone (TSH), total thyroxine (T4), total triiodothyronine (T3), free T4, free T3, intact ...
To assess whether biotin supplements cause interference in routine clinical laboratory testing of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (T4), parathyroid hormone (PTH) troponin-T and N-terminal pro b-type natriuretic peptide (NTproBNP). Three adult volunteers...
2. Materials and Methods 2.1. Study design Plasma samples from 728 patients aged ≥ 18 years undergoing routine thyroid stimulating hormone (TSH), procalcitonin (PCT), or human immunodeficiency virus (HIV) testing had blood biotin levels evaluated. All PCT and HIV samples were collected from patie...
While biotin interferences have now been well described for hormones, including thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), parathyroid hormone (PTH), and 25-hydroxy vitamin D (25OHD), serological markers have received less attention in the literature, ...
We analysed the Pit-1 gene of five patients with combined deficiency of GH, PRL and TSH. In three patients, we identified three point mutations in the Pit-1 gene, Pro24Leu, Arg143Gln, and Arg271Trp, located on the major transactivation region, POU-specific domain, and POU-homeodomain, ...
比如在甲状腺功能检测中,生物素会导致FT4和FT3假性偏高、TSH假性偏低,这就和甲亢的指标表现类似了。 2017年,一名患者因服用生物素导致心肌肌钙蛋白评估结果不准确、延误了治疗,最后不幸去世。美国食品药品监督管理局(FDA)因此警告公众、医护人员和实验室人员,生物素可能会干扰某些实验室检查并得出误导性的结果。
The patient in the above case is taking a high dosed biotin supplement and had tests of concern. Her low TSH and high T4 could be associated with biotin use, especially if she does not have any symptoms of hypothyroidism. She should be counseled to hold biotin prior to labs as well as...
Biotin interference: evaluation of a new generation of electrochemiluminescent immunoassays for high-sensitive troponin T and thyroid-stimulating hormone testingbiotinimmunoassaysinterferencethyroid-stimulating hormone (TSH)troponinBackground: Biotin is currently a matter of concern for laboratories using biotin-...