One such approach, involves the addition of microbial components (pathogen-associated molecular patterns; PAMPs), that can stimulate strong immune responses, into subunit vaccine formulations. The conjugation of PAMPs to subunit antigens provides a means to greatly increase vaccine potency, by targeting...
higher-level mathematical and computational concepts; (ii) availability of texts that can give a flavor of how contemporary biological problems are approached with quantitative methods; (iii) expectations to cover specific mathematical (or biological) content rather than teach a problem-solving approach....
a, Problem formulation: given unperturbed gene expression (green) and applied perturbation (red), predict the gene expression outcome (purple). Each box corresponds to an individual gene. Arrows indicate change in expression. b, GEARS model architecture. (i) For each gene in the unperturbed state...
Growth kinetics of microorganisms processes involves a parameter estimation problem, which is usually solved by using simulation techniques. A different approach is presented. It is based on a trust-region algorithm for nonlinear least squares problems with bound constraints. The global convergence propert...
Environmental Biotechnology: A Biosystems Approach This book focuses on the way in which biotechnology has been a vital buffer between people, pollution and the environment and discusses the systems approach thta is need to maximize the sustainability of efforts in this field and improve... D Valle...
This manuscript describes a pilot study in ethics education employing a problem-based learning approach to the study of novel, complex, ethically fraught, ... RM Berry,J Borenstein,RJ Butera - 《Science & Engineering Ethics》 被引量: 22发表: 2012年 Exploring the Effects of Active Learning on...
Antibiotic resistance is a reemerging problem facing health care settings globally. Among the possible routes to offset this challenge is to try and find out means of combating resistance and pathogenecity by reducing the virulence rather than growth inhibition. One of the most promising proposals ...
whereas the MS1 modification addresses a problem arising from differences between the prokaryotic and eukaryotic expression systems. We also present evidence that MS2 modifications contribute to both aspects. It is interesting that our empirical approach to derive an optimized gRNA was in line with recen...
MicroRNAs (miRNA's) constitute a large family of non coding RNAs that function to regulate gene expression.Wet lab experiments usually used to classify the... A Dubey,U Chouhan - 《International Journal of Bioinformatics Research》 被引量: 6发表: 2011年 Special-study modules in a problem-base...
A highly-interdisciplinary approach has been developed for minimizing the immunogenicity of films, coatings, microcapsules and other nano-structured materials fabricated from designed polypeptide chains. It is to base the amino-acid sequences on solvent-exposed regions in the folded states of proteins fr...