基于遗传学和酶学的层面对生物合成途径和催化机制的理解也进一步促进了药物和生物控制剂的开发。本期Engineering Microbiology专刊《Synthetic biology and biosynthesis of natural products》研究范围涵盖了新颖天然产物发现和挖掘生物合成基因簇激活、鉴...
Biosynthesis is the generation of natural products through enzymatic reactions, as in cellular metabolism. Successive enzymatic reactions by a number of enzymes are generally required to achieve a single biologically active compound. Biosynthesis can be exploited for chemical synthesis in vitro or in cell...
The biosynthesis of natural products.doi:10.1002/chin.201409269HumansTreatment RefusalForensic PsychiatryCommitment of Mentally IllCriminal LawCivil RightsSocial JusticeEthics, MedicalMentally Ill PersonsPrisonersNo abstract availableHailesHelen ClaireHealth Law in Canada...
a, Structure of streptoseomycin (1) and structurally related natural products nargenicin (2), coloradocin, nodusmicin and branimycin. b, The stm gene cluster from S. seoulensis A01 and the ngn gene cluster from N. argentinensis ATCC 31306. c, Proposed biosynthetic pathway for 1. d, Pr...
Here we report the function of β-NAD in secondary metabolite biosynthetic pathways, in which the nicotinamide dinucleotide framework is heavily decorated and serves as a building block for the assembly of a novel class of natural products. The gatekeeping enzyme of the discovered pathway (SbzP) ...
Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels–Alderase. Nat. Catal. 4, 223–232 (2021). CAS PubMed PubMed Central Google Scholar Zhang, B. et al. Enzyme-catalysed [6 + 4] cycloadditions in the biosynthesis of natural products. Nature...
The biosynthesis of natural products in a fast growing and easy to manipulate heterologous host system, such as Escherichia coli, is of increasing interest in biotechnology. This procedure allows the investigation of complex natural product biosynthesis and facilitates the engineering of pathways. Here ...
Indole-3-acetic acid (IAA) (Structure 4.1) has been conclusively shown to be a natural hormone, ubiquitously present in higher plants. Evidence is gradually accumulating that there are indolic auxins other than IAA naturally occurring in several plants,
Natural products containing carbon-phosphorus bonds (phosphonic and phosphinic acids) have found widespread use in medicine and agriculture. Recent years have seen a renewed interest in the biochemistry and biology of these compounds with the cloning of the biosynthetic gene clusters for several family ...
The leaves of Catharanthus roseus (L.) G. Don produce the first natural drugs used in cancer therapy – the dimeric terpenoid indole alkaloids vinblastine ... M Sottomayor,IL Cardoso,LG Pereira,... - 《Phytochemistry Reviews》 被引量: 104发表: 2004年 Biosynthesis of Natural Products. VI. ...