Biosynthesis of enediyne antitumor antibiotics. Curr. Top. Med. Chem. 8, 448-459.Liu W,Christenson S D,Standage S,et al.Biosynthesis of the enediyne antitumor antibiotic C-1027. Science . 2002Liu W,Christenson S D,Standage S,et al.Biosynthesis of the enediyne antitumor antibiotic C-1027....
Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. Journal of Antibiotics . 2010; ... Y Chen,Y Min,GP Horsman,... - 《Journal of Antibiotics》 被引量: 86发表: 2010年 Observations in the chemistry and biology of cycli...
Solving the mystery of enediyne biosynthesis The biosynthetic intermediate of the common core of enediyne natural products has been enigmatic for decades. Now, researchers report the identification of a diiodotetrayne compound as the universal enediyne biosynthetic intermediate. Max B. Sosa Michelle ...
ChemInform Abstract: Biosynthesis of Dynemicin A, a 3-Ene-1,5-diyne Antitumor AntibioticantibioticsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was ...
Synthesis of the core enediyne structure of esperamicin-calichemicin class of antitumor antibiotics The core structure of esperamicin-calichemicin series, bicyclo[7.3.1]enediyne 2, was synthesized in 9% overall yield in eight steps from cyclohexane-1,2-di... FK Koga - 《Tetrahedron Letters...
Not surprisingly,antibioticproduction has been a major focus of interest, and hundreds of biosynthetic gene clusters have been sequenced. Among the many classes of antibiotics, two have received particular attention: those made by modularpolyketidesynthases and those assembled by modularnonribosomal peptide...
The dehydratase-encoding gene has been used as a probe to successfully identify the gene cluster of the enediyne antibiotic C-1027 (ref. 18). To search for these two gene loci, the genomic deoxyribonucleic acid (DNA) of S. sp. KIB-H033 was subjected to Illumina sequencing. Using KSα ...
Production of Octaketide Polyenes by the Calicheamicin Polyketide Synthase CaIE8: Implications for the Biosynthesis of Enediyne Core Structures.The article focuses on the ability of calicheamicin polyketide synthase CalE8 in producing octaketide polyenes and the implications for enediyne core structures...
Enediyne natural products are extremely potent antitumor antibiotics with a remarkable core structure consisting of two acetylenic groups conjugated to a double bond within either a 9‐ or 10‐membered ring. Biosynthesis of this fascinating scaffold is catalyzed in part by an unusual iterative type I...
ORIGINAL ARTICLE The Journal of Antibiotics (2016) 69, 731–740 & 2016 Japan Antibiotics Research Association All rights reserved 0021-8820/16 www.nature.com/ja Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic ...