ProstateHumansProstatic NeoplasmsDisease ProgressionBiopsyMaleHopeClyne M.doi:10.1038/nrurol.2013.115Melanie ClyneNat Rev UrolNature Reviews UrologyClyne M. Prostate cancer: does a negative second biopsy give patients false hope? Nat Rev Urol. 2013;10(6):310....
Besides, liquid biopsy has potential applications even in the field of lung cancer screening. If low-dose computerised tomography (LDCT) has demonstrated a role in lung cancer screening for heavy-smoker patients [159,160], the detection of false-positive cases is one of the major concerns [161...
Identifying genetic mutationsFalse-negative results[54,55,62,77] ExosomeBody fluidsExtraPEG methodNanoparticle tracking analysis Electron microscopy Western blotting Mass spectroscopy Next generation sequencingMonitoring the cancer progression Identifying genetic mutations ...
“When we found it was regulated the same way certain cells grow uncontrollably, we started studying hBD-3 in the context of oral cancer," added Weinberg, who is chair of the Department of Biological Sciences at the Case Western Reserve School of Dental Medicine. “Imagine our ...
The purpose of this report is to emphasize the possibility of false-negative biopsies for testicular intraepithelial neoplasia (TIN) in men with high-risk features of testicular cancer and to review the relevant literature. At the Norwegian Radium Hospital patients in this category are offered the ...
ability to predict PCa in patients with elevated PSA and a negative biopsy, but they are still considered at risk and may require a repeated biopsy. Furthermore, other studies have concluded that PCA3 has limited value in predicting aggressive cancers6. Similarly, although the TMPRSS2:ERG ...
The reduction of PSA plus PSA density values and the downgrading of PI-RADS score to ≤ 3 allow avoiding a repeated prostate biopsy in men with initial mpMRI PI-RADS score 5 lesion and negative biopsy histology. 中文翻译: PI-RADS 在日常临床实践中评分为 5 的男性活检组织学阴性:肉芽肿性前列...
to distinguish Her2+ from triple negative breast cancer subtypes in clinical serum samples [92]. Other microfluidic chips targeting specific exosome subpopulations have shown potential to be developed as early detection and diagnostic tools applicable to clinical samples, such as EVs on demand chip (EV...
Suspicious nodules detected by radiography are often investigated by biopsy, but the diagnostic yield of biopsies of small nodules is poor. Here we report a method—NIR-nCLE—to detect cancer at the cellular level in real-time during biopsy. This technology integrates a cancer-targeted near-infrar...
Liquid biopsy is less invasive than tumour biopsy, but, to date, no liquid biopsy biomarkers have been clinically approved for RCC diagnosis. Circulating tumour cells (CTCs) seem less suitable than extracellular vesicles (EVs) for cancer detection in SRMs, owing to low epithelial cell adhesion mol...