and TargetingDrug Discovery ToolsDrug Interactions of Antimicrobial AgentsDrug Metabolism and PharmacokineticsDrug Metabolism, Pharmacokinetics and BioanalysisDrug Safety and PharmacovigilanceDrug StabilityDrug-Loaded Nanofibers: Controlled and Sustained ReleaseElectrospun and Electrosprayed Formulations for Drug Delivery...
[25] modeled the response of p53 to the anti-tumor drug Nutlin and determined the extra-cellular concentration and dynamics of the anti-tumor drug with the help of the available pharmacokinetics data of Nutlin oral delivery in mice. It can be noted that due to the complex of Nutlin and ...
However, if this criterion is not met, but the highest dose strength is soluble in the pH range, a biowaiver may be supported by dose-proportional pharmacokinetics in a range that includes the highest single therapeutic dose. This difference has been supported by the International Consortium for...
2.7.1. Development and Verification of the Pharmacokinetic Model The PKPlus™ module in GastroPlus® version 9.8 (Simulations Plus Inc., Lancaster, CA, USA) was used to develop the pharmacokinetics (PK) model. For this purpose, a plasma-concentration profile of 5 mg IV infusion of metopro...