mRNA encoded antibodies;SARS–CoV-2;COVID-19;Trastuzumab;mRNA-vaccines;pharmacokinetics;immunodeficient;NOD/SCID/J;biopharmaceutics 4.0;IVT mRNA 1. Introduction Although equipped with a finite gene repertoire,
Figure 1. Illustration of topical ocular drug administration and pharmacokinetics. Drug concentrations in ophthalmic eyedrop solutions are usually in the range of 0.1% to 4%, but such drug concentrations in solution are difficult to reach for hydrophobic drugs, and therefore many topical eyedrop fo...
PBPK: physiologically based pharmacokinetics; BSV: between-subject variability; WSV: within-subject variability; Cmax: maximum concentration; tmax: time to maximum concentration; BE: bioequivalence; DLM: diffusion layer model; PE: prediction error: T/R: test/reference; CI: confidence interval; VBE: ...