In short, the oral absorption and hence bioavailability of drug is determined by the extent of drug solubility and permeability.A. V. GothoskarS. M. KhangaonkarPharmaceutical ReviewsGothoskar AV. Biopharmaceutical Classification of Drugs. Pharmainfo.net 2005; 3(1) http://www.pharmainfo.net/...
Biopharmaceutical Classification Of Drugs 来自 ResearchGate 喜欢 0 阅读量: 21 作者:AV Gothoskar,SM Khangaonkar 摘要: ral route of drug administration is, still the route of choice for the formulators. The in vivo performance of orally administered drug depends upon its solubility and tissue ...
Properties such as biopharmaceutical solubility and intestinal permeability are described, along with methods of assessing them and interactions between drug transport and absorption across GIT membranes and levels of metabolism. The main biopharmaceutical classification systems for drugs are presented and ...
Biopharmaceutical classification of drugs using intrinsic dissolution rate (IDR) and rat intestinal permeability for tested drugs. The minimum and maximum intestinal permeabilities in rat intestine were determined to be 1.6×10 and 2×10cm/s, respectively. Four classe... P Zakeri-Milani,M Barzegar-...
The aim of this study was to classify some markers of common herbs used in Western medicine according to the Biopharmaceutical Classification System (BCS). The BCS is a scientific approach to classify drug substances based upon their intestinal permeability and their solubility, at the highest single...
Excipients are generally pharmacologically inert, but can interact with drugs in the dosage form and the physiological factors at the site of absorption to... R Panakanti,AS Narang - 《Pharmaceutical Research》 被引量: 55发表: 2012年 Biopharmaceutical classification system: A strategic tool for ora...
The Biopharmaceutical classification system (BCS) was introduced By Amidon et al., (1995) as a method for classifying drug substances based on their dose/s... B Vikaas,N Arun - 《International Research Journal of Pharmacy》 被引量: 6发表: 2012年 Vandemicum of Nanogold and Nanosilver to ...
Application of the Biopharmaceutical Classification System in Clinical Drug Development—An Industrial View Cook, J. et al., " Application of the BIopharmaceutical Classification System in Clinical Drug Development -- An Industrial View, " The AAPS Journal, ... Jack,Cook,William,... - 《Aaps Jo...
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This review attempts to address the critical molecular and thermodynamic aspects governing the physicochemical properties of such systems. A brief introduction to Biopharmaceutical Classification System, solid dispersions, glass transition, and solubility advantage of amorphous drugs is provided. The objective ...