Shea and Kim, “Influence of Strain on Chemical Reactivity. Relative Reactivity of Torsionally Strained Double Bonds in 1,3-dipolar cycloadditions”, 1992, J Am Chem Soc, vol. 114, No. 12, pp. 4846-4855. Speers, et al. “Activity-Based Protein Profiling in Vivo Using a Copper(I)-...
The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: Two new functionals and systematic testing of four M06-class functionals and 12 other functionals. Theor. Chem. Acc. 2008, 120, 215–241....
DC-SIGN antagonists, a potential new class of anti-infectives Curr. Med. Chem., 19 (7) (2012), pp. 992-1007, 10.2174/092986712799320664 View in ScopusGoogle Scholar [152] P. Valverde, A. Ardá, N.C. Reichardt, J. Jiménez-Barbero, A. Gimeno Glycans in drug discovery MedChemComm, ...
One class of inteins, termed “split inteins,” involves two complementary half inteins, termed the N-intein and C-intein, that associate selectively and extremely tightly to form an active intein enzyme (Shah N. H., et al, J. Amer. Chem. Soc. 135: 18673-18681; Dassa B., et al., ...
Hormones communicate among organs and tissues to regulate various functions as a class of signaling molecules [48]. Human chorionic gonadotropin (hCG), an important pregnancy diagnostic marker, is a glycoprotein hormone that stimulates steroid hormone and progesterone production in the luteum [49]. ...
This class of metal complexes has already shown good inhibition activity toward kinases [31] and topoisomerases [32], and the remarkable ability to damage mitochondria [30]. These results point to other factors than oxidative assets in determining the reactivity of these compounds. A more ...
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Table 1. Ablation study: mean class accuracy decreases over various models. The temporal network performs better than PointNet++, which suggests that the sequential data might be more important than 3D protein structure in protein fold classification and/or that PointNet++ is suboptimal for the str...
However, most molecules of this class, when used in IBD treatment, also elicit adverse side effects and present bioavailability issues. One strategy to overcome these drawbacks involves the application of drug delivery systems. In the last 5 years, research has focused on cyclosporine and ...
AAD12 and investigated its proteome maps and osmolyte accumulation strategy under salt stress. Metagenomic studies from halophilic environments have led to the discovery of the "Nanohaloarchaea", a new class of uncultivated microorganisms with a unique amino acid combination Microorganisms 2017, 5, 25...