DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA methylated state, whereas the Polycomb repressive complexes regulate the unmethylated CpG-rich promoters of dev...
Automatic cell type annotation methods are increasingly used in single-cell RNA sequencing (scRNA-seq) analysis due to their fast and precise advantages. However, current methods often fail to account for the imbalance of scRNA-seq datasets and ignore in
In contrast, “deep” architectures or “deep learning” [79] is abstracted by multiple hidden layers between input and output layer. In each layer the information is passed on to each unit as a weighted sum of units from previous layers with some – usually nonlinear – transformation in ...
In this study, we propose iDNA-ABF, a multi-scale deep biological language learning model that enables the interpretable prediction of DNA methylations based on genomic sequences only. Benchmarking comparisons show that our iDNA-ABF outperforms state-of-
Chemistry by the Case: Integrated Case Teaching and Team Learning. Introduces a chemistry unit, the "Evolving Atom", based on a problem-based learning approach designed for non-science majors. Uses the case method to addre... FJ Dinan - 《Journal of College Science Teaching》 被引量: 26发表...
This is, however, not true for all genes, and we can conclude that the pathway is not evolving as a unit but each gene follows its own history, as has been shown previously for Bacteria and Archaea [25, 26]. For a better understanding of the gene-duplication history, further genome ...
A fundamental question in protein evolution is whether nature has exhaustively sampled nearly all possible protein folds throughout evolution, or whether a large fraction of the possible folds remains unexplored. To address this question, we defined a se
The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth and repair. Here we generate self-organizing human pluripotent stem cell-derived epicardioids that ...
CellML [1] and NeuroML [2] are such examples, but the Systems Biology Markup Language (SBML) [3], being adopted by more than 180 software systems ranging from simulators to model editors and databases [4], has so far been the most successful standard model exchange format in this field....
SET domains (Figure 1h and SCOP super- family: 82199) have a fold unique for SAM binding pro- teins – a substrate binding subdomain between two structural repeats, which may have evolved by duplication of 3-stranded unit with a generic ligand binding role [71,72]. Those repeats have a...