What is the translation process? Understand the process of translation. Learn what happens during the initiation, elongation, and termination phase...
The process of translation creates a polypeptide chain that still needs to be modified before it can work properly as a new protein. The primary structure of aprotein, its amino acid sequence, represents only a small part of its eventual function. The protein is modified after translation by f...
Here, we review the remarkable range of discoveries that genome-wide association studies (GWASs) have facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. In the introductory sections, we provide a background for this review, summariz...
1b and Supplementary Table 1). Many of the highly abundant proteins were ribosomal proteins and translation factors, which we reasoned could bind to the beads nonspecifically and rank highly due to their sheer abundance in bacteria. At the same time, RNAP-interacting proteins expressed at low ...
steps leading to the synthesis of a polypeptide is ___. transferring of information from DNA to messenger RNA --> RNA leaves Nucleus and carries information to ribosomes --> translation of an RNA nucleotide sequence into a sequence of amino acids --> linking of nucleotides to form a polypep...
Recently, the transcriptome of Drosophila melanogaster was shown to contain thousands of smORFs of different classes that actively undergo translation, which produces peptides of mostly unknown function. Here, we present a comprehensive analysis of smORFs in flies, mice and humans. We propose the ...
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spannin
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RNA modifications are widespread in biology and abundant in ribosomal RNA. However, the importance of these modifications is not well understood. We show that methylation of a single nucleotide, in the catalytic center of the large subunit, gates ribosom
Communication by extracellular signals usually involves six steps: (1) synthesis and (2) release of the signaling molecule by the signaling cell; (3) transport of the signal to the target cell; (4) detection of the signal by a specific r... H Lodish,A Berk,SL Zipursky,... - 《W....