MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate...
Plausibly, increasing the rate of sperm transfer may be another critical step in increasing a male’s fitness. This “fast sperm transfer” hypothesis posits that, in addition to using a palp with more sperm, a male that faces cannibalism attempts may also benefit in fitness by increasing the ...
the models with and without adversarial training on two datasets (5hmC_M.musculusand6mA_F.vesca), randomly selected from the datasets. From Fig.1J, we can see that the models with adversarial training achieve lower test loss than that without adversarial training although the loss reduction rate...
We found 630 DEGs associated with 40 KO terms that could be enriched in the MAPK signaling pathways. Of these, 625, 602, 604, and 620 DEGs were expressed in YT-h, YT-y, YT-f, and YT-p, respectively. On the other hand, 627, 605, and 590 DEGs were expressed in RT-h, RT-y,...
As a result, model organisms began to outpace other systems not only in terms of their inherent convenience, but also in terms of the availability of infrastructure to study them. This difference was highlighted by the early genome projects, which for obvious reasons focused on model organisms. ...
Muller's ratchet must have had strong effect on accumulation of these mutations, given that the number of mutant-free chromosomes in a population is positively correlated with the effective population size (N e) [6, 18]. Because of the usual small N e values of mammals, mutant-free neo-Y...
Optimal foraging theory (OFT) can predict the composition of a species’ diet under particular conditions. During periods of abundance, herbivore diets should contain relatively few species as animals maximize their energy intake by concentrating on the best food plants available in terms of energy an...
The ICAP framework, which has its roots in a cognitive perspective of learning, reframes active learning in terms of the level of cognitive engagement asked of students in learning tasks. ICAP refers to Interactive, Constructive, Active, and Passive levels of cognitive engagement (Chi and Wylie 20...
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The ...
Identification of novel Arabidopsis thaliana upstream open reading frames that control expression of the main coding sequences in a peptide sequence-dependent manner. Nucleic Acids Res. 43, 1562–1576 (2015). Article CAS PubMed PubMed Central Google Scholar Combier, J. P., de Billy, F., ...