show that aneuploid cells are more sensitive to SAC inhibition than diploid cells. Aneuploid cells were found to depend on an intact SAC for accurate chromosome segregation and long-term survival, implicating the SAC as a potential therapeutic target in aneuploid cancers. CAS PubMed PubMed Central...
Ca2+, and to a lesser extent, Zn2+ are two common targets with a bevy of available small-molecule indicators. However, their specificity has been questioned, and long-term toxicity remains a concern93,94. Moreover, they cannot be targeted to specific cell populations. Fortunately, it is ...
A term used to characterize pluripotency at the level of a cell population, and which refers to the ability of this population to give rise to cellular progeny of each of the three main germ layers. Gene count The number of expressed genes (that is, the number of genes with non-zero exp...
Protein complexes and conserved protein complexes are detected from the PPI subgraphs induced by the individual genes that are ranked top by the RWR algorithm. Full size image In order to evaluate the results of our pipeline, we utilize multiple perspectives of GO term analysis. First, the GO ...
The first term ensures that the tasks in each group are as close to the group center as possible, and the second term ensures that the group centers have the graph structure that is represented by K. Putting all these components together, we propose the bipartite block-wise sparse multi-task...
Oophorectomy = another term for ovariectomy, the surgical removal of the female reproductive organs, ovaries. Paced Auditory Serial Addition Task (PASAT) = a cognitive task given to MS patients to measure auditory information processing speed and flexibility, as well as calculation ability. ...
This illegal activity, provokes long-term and partially irreversible impacts on local assemblages, and exacerbates the effects of other sources of impact, with the consequence that recent analysis carried out at EU level defined the Mediterranean shallow rocky subtidal habitats in a vulnerable state (...
At Synthetic Genomics, Inc [which Venter founded with his long-term collaborator, the Nobel laureate Ham Smith], we can feed digital DNA code into a program that works out how to re-synthesize the sequence in the lab. This automates the process of designing overlapping pieces of DNA base-...
With the increasing availability of large-scale biology data in crop plants, there is an urgent demand for a versatile platform that fully mines and utilizes the data for modern molecular breeding. We present Crop-GPA ( https://crop-gpa.aielab.net ), a c
K. & Stephanopoulos, G. J. Stabilized gene duplication enables long-term selection-free heterologous pathway expression. Nat. Biotechnol. 27, 760–765 (2009). Article CAS PubMed Google Scholar Yang, S. Q. et al. Orthogonal CRISPR-associated transposases for parallel and multiplexed chromosomal ...