Technology Feature|12 September 2024 Red light, green light: flickering fluorophores reveal biochemistry in cells A mysterious afterglow in a pandemic side project leads to a new method for observing proteins that interact in living cells. Alla Katsnelson ...
select article Impact of Serum Insulin-Like Growth Factor 1 on Hematopoietic Stem Cell Transplantation Outcome in Pediatric Cancer Patients Research articleOpen archive Impact of Serum Insulin-Like Growth Factor 1 on Hematopoietic Stem Cell Transplantation Outcome in Pediatric Cancer Patients Deborah Betzman...
Cancer Metastasis Oncology Health Coursera Plus Course Auditing Coursera Johns Hopkins University Kenneth J. Pienta Health & Society Medicine & Pharmacology Sci: Biology & Life Sciences USA Beginner 5-12 Weeks 1-4 Hours/Week Yes, Paid Exam and/or Final Project Paid Certificate 42.0...
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more...
With the rapid advancements in spatial transcriptome sequencing, multiple tissue slices are now available, enabling the integration and interpretation of spatial cellular landscapes. Herein, we introduce SpaDo, a tool for multi-slice spatial domain analy
Sex differences exist in the risk of developing type 1 and type 2 diabetes, and in the risk of developing diabetes-associated complications. Sex differences in glucose homeostasis, islet and β cell biology, and peripheral insulin sensitivity have also b
Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited. To discov
Guest Joey Azofeifa is CEO and Founder of Arpeggio Biosciences, a company developing new medicine to target homeostasis in cancer and chronic kidney disease using advances in AI and RNA-sequencing. Drug developers – from small startups to Fortune 500 companies – often lean on the help of Cont...
Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity and heterogeneity among PLCs remains challenging. Here, using single-cell RNA sequencing, spatial transc
Proteins including FUS, hnRNPA2, and TDP-43 reversibly aggregate into amyloid-like fibrils through interactions of their low-complexity domains (LCDs). Mutations in LCDs can promote irreversible amyloid aggregation and disease. We introduce a computation