Dimitrios Katsaounis, Nicholas Harbour, Thomas Williams, Mark AJ Chaplain & Nikolaos Sfakianakis 2269 Accesses 6 Altmetric 2 Mentions Explore all metrics Abstract We introduce in this paper substantial enhancements to a previously proposed hybrid multiscale cancer invasion modelling framework to ...
Artificial metalloenzymes (ArMs) integrated within whole cells have emerged as promising catalysts; however, their sensitivity to metal centers remains a systematic challenge, resulting in diminished activity and turnover. Here we address this issue by i
Desensitization occurs when LBD clamshells are maximally closed around Glu; however, instead of using this energy to pull apart the M3 ion channel gate, LBD dimer pairs roll away from each other, which minimizes the separation between D2 interfaces and reduces the tension applied to the M3 heli...
c Performance of SpaDo when using cell type annotation from original paper or Seurat v4 with different value of parameter “Resolution” on osmFISH, seqFISH, and STARmap datasets. R resolution. d Performance of SpaDo when using different spot deconvolution methods. e Performance of SpaDo when ...
the chromatin was labeled in the previous cell cycle. We then performed chromatin compaction class analysis using DAPI intensity (Methods) of 3D-SIM imaged fixed cells and mapped the distribution of chromatin label within the compaction class and plotted it as a bar plot.CThe labeling scheme to...
Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can yield detrimental outcomes, a role in facilita
RKP, EB, and ALE wrote the paper. All authors contributed to editing the final manuscript. The author(s) read and approved the final manuscript. Authors’ information Twitter handles: @RajivParvath (Rajiv K. Parvathaneni); @edbertolini (Edoardo Bertolini); @_Daniel_Vera (Daniel Vera); @...
only one locomotory mode, representing a simplified version of the locomotory categorization described above. We followed classification styles used in [9,10,68] to assign these generalized classifications and extended them based on their similarity to taxa included in this paper for ease of ...
The dropout scheme was kept the same as during the AF training. The PCA111 was performed using the Scikit-learn Python library112. To analyse the set of structures, we performed the PCA in Cartesian coordinates for two sets of atoms: (a) PCAa, which includes the N, Cα, C, O atoms...
Using the csparc2star.py function in pyEM47, these particles were exported to RELION48 v.3.1.3, where a 3D classification scheme using a soft mask around Nog2/H92 was used to further separate 86,273 Nog2-bound particles. These particles were re-imported into cryoSPARC v.3.2 for a 3D ...