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Current small-molecule inhibitors of KRAS(G12C) bind irreversibly in the switch-II pocket (SII-P), exploiting the strong nucleophilicity of the acquired cysteine as well as the preponderance of the GDP-bound form of this mutant. Nevertheless, many oncoge
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wrote the paper and have read and agree to the published version of the manuscript. Funding DMF was funded by the American Cancer Society. Work in the SMR laboratory was funded by the WM Keck Foundation, US National Institutes of Health (NIH) Director’s Pioneer Award DP1-AG072751, and ...
designed all the experiments, interpreted data, and wrote the paper. X.H. performed all the experiments and the scRNA-seq data analysis. W.G. participated in all the animal surgery. J. Zhang and Y.L. were involved in stomach sample processing, gastric stem cell isolation and cell line ...
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c Performance of SpaDo when using cell type annotation from original paper or Seurat v4 with different value of parameter “Resolution” on osmFISH, seqFISH, and STARmap datasets. R resolution. d Performance of SpaDo when using different spot deconvolution methods. e Performance of SpaDo when ...
Gene expression in Escherichia coli is controlled by well-established mechanisms that activate or repress transcription. Here, we identify CedA as an unconventional transcription factor specifically associated with the RNA polymerase (RNAP) σ70 holoenzy