Spatial molecular data has transformed the study of disease microenvironments, though, larger datasets pose an analytics challenge prompting the direct adoption of single-cell RNA-sequencing tools including normalization methods. Here, we demonstrate tha
combinations on the growth ofS. miltiorrhiza, we designed thirty-one different inoculation treatments using the method of complete factorial design. The inoculums of different treatments were evenly mixed in equal amounts to prepare 200 spores per 10 g of soil according to the design scheme in ...
In terms of glutamatergic afferent projections reaching the STN, analysis of human brain tissue has identified VGLUT1 protein, indicative of afferent terminals from the cortex (and possibly other excitatory brain areas positive for this subtype of VGLUT), localized to the dorso-caudal extent of the...
However, these aspects have a lower potential for biomimetic material systems and few parallels can be drawn with other artificial material systems; they are therefore not discussed further in this paper. 3.2. Resilience through Self-Repair of Damage The self-repair of wounds is a typical life-...
1. Introduction The main question of this paper is whether and why molecular biology can be considered a discipline of its own. (This paper is in parts a translation and adaptation of my 2012 bachelor’s thesis at the University of Salzburg under Michael Breitenbach’s supervision. When discuss...
Gene expression inference with deep learning [github][paper] This deals with a specific prediction task, namely to predict the expression of specified target genes from a panel of about 1,000 pre-selected “landmark genes”. As the authors explain, gene expression levels are often highly correla...
Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can yield detrimental outcomes, a role in facilita
With the rapid advancements in spatial transcriptome sequencing, multiple tissue slices are now available, enabling the integration and interpretation of spatial cellular landscapes. Herein, we introduce SpaDo, a tool for multi-slice spatial domain analy
The HEK293 human cell lineage is widely used in cell biology and biotechnology. Here we use whole-genome resequencing of six 293 cell lines to study the dynamics of this aneuploid genome in response to the manipulations used to generate common 293 cell d
foundation of the field of honeybee behavior, and continue to be cited today. We provide clear evidence that several of these papers contained erroneous information, and many of them contain duplicated and manipulated data. Importantly, the report became a critique not of a single paper, but of...