摘要 Innate immunity, cell death andinflammationunderpin many aspects of health and disease. Upon sensing pathogens, pathogen-associated molecular patterns or damage-associated molecular patterns, the innate immune system activates lytic, inflammatory cell death, such aspyroptosisand PANoptosis. These genetic...
To survive in the absence of the ability to take up extracellular nutrients, growth-factor-deprived cells engage in autophagic degradation of macromolecules and organelles. This is a finite survival strategy, ultimately resulting in cell death. In contrast, increases in ligand signaling instruct cells...
factor•5.Constitutiveactivationofsignalingproteinsdownstreamfromthe receptor 6 2.Evadinggrowthsuppressors •Cancercellsmustovercomeprogramsthatnegativelyregulatecellproliferation •Theseprogramsdependontheactionoftumorsuppressorgenesthatnormallygovernthedecisionofcellstoproliferateortoundergoprogramcelldeath(apoptosis)•...
Cell death, or conversely cell survival, is a major biological phenomenon. Just as cell proliferation and cell differentiation, cell death is a choice that a cell has to make, sometimes voluntarily, other times accidentally. As such, cell death serves a purpose in the biology of a ...
and are thus part of a broad signaling network. The disruption of these mechanisms often causes developmental abnormalities, and factors that trigger cell death can directly contribute to the pathogenesis of many diseases, including cancer, neurodegenerative diseases, and tissue injury. Additionally, in...
Cancer Cell 24, 257–271 (2013). This work defines a dominant role of IL-11 as a driver of procarcinogenic chronic inflammation in the intestine. Article CAS PubMed Google Scholar Grivennikov, S. I. IL-11: a prominent pro-tumorigenic member of the IL-6 family. Cancer Cell 24, 145...
and are thus part of a broad signaling network. The disruption of these mechanisms often causes developmental abnormalities, and factors that trigger cell death can directly contribute to the pathogenesis of many diseases, including cancer, neurodegenerative diseases, and tissue injury. Additionally, in...
et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. 31, 1062–1079 (2012). CAS PubMed PubMed Central Google Scholar Obeid, M. et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nature Med. 13, 54–...
Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms. J Biol Chem. 2018;293:16348–63. PubMed PubMed Central CAS Google Scholar Deniz G, Akdis M, Aktas E, Blaser K, Akdis CA. Human NK1 ...