An important note here is that there is certainly a difference between cells with gliomagenic capacity and the reality of which cells originate tumors in vivo. There are two prevailing theories addressing glioma cellular origin(s). The first is a scenario where a differentiated somatic cell ...
a simple and interpretable model that combines TME classes with PD-L1 expression achieved a significantly higher accuracy for response prediction. Of note, our analysis revealed that a specific group of patients with dMMR/MSI-H tumors remain unresponsive to anti-PD-1 immunotherapy. This finding has...
Additional information Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary Information Additional file 1: Supplementary Table 1. Number of eggs laid by each Aedes aegypti female in treatment 5. Additional file...
Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary Information Additional file 1: Fig. S1. Impact of the nutrient environment on oxytetracycline production in S. rimosus. Production by ...
Additional information Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary Information 13059_2022_2770_MOESM1_ESM.pdf Additional file 1: Supplementary figures: Figure S1. Pipeline workflow for identification of...
(2) an alternative configuration wherein contig1 and contig2 form two independent circles with contig3, respectively (Fig.1D). However, as the length of contig3 exceeded the reach of our sequencing long reads, there were no reads available to directly span this repeating region. Consequently, ...
4). We found that all the Methanomassiliicoccales genomes lack the homologs of the HdrE subunit (hdrE) but carry the Fpo-like subunits (fpoKLMN), which may directly interact with the HdrD subunit (hdrD) to form the energy-converting ferredoxin:heterodisulfide oxidoreductase complex (Fig.4...
(a1, a2, a3, and a4) and F2motifs (b1, b2, b3, and b4) cannot be fully merged to form a bifunctional motif. Instead, the bi-functional networks of combination are derived from non-core motifs that can achieve both oscillation and adaptation, such as the structure skeletons c1and c2...
Fig. 3 presents in a different form the relationships shown in Fig. 2a at log = 0. Note that the same proteins predominate at the extremes of oxygen fugacity represented in Fig. 3 and in Fig. 2a (reducing – early Golgi; oxidizing – vacuole) and that the reference model protein of ...
(ABRE) is the major cis-element for ABA-responsive gene expression, and the ABRE-dependent gene expression is regulated by ABRE-binding factor (ABF). In peach, PpABF2 interacted with PpTCP20 to form heterodimers and regulate bud endodormancy. PpyABF3 could bind to the promoter ofPpyDAM3to ...