Sex chromosome-encoded protein homologs: current progress and open questions Here, the authors examine and discuss the functional complexity and cellular implications of X–Y pairs, homologous genes expressed in the human sex chromosomes. Michael C. Owens Amber Yanas Kathy Fange Liu Review Article...
the past 20 years. Here, we speak to Sarah E. O’Connor, Benjamin F. Cravatt and Chengqi Yi about the major changes that have affected the field, the advances that have affected them and their research, and their thoughts about the most important questions currently facing chemical biologists...
system. Generally, MDS patients have a poor prognosis, with a median overall survival of only 5 years. MDS patients who progressed to AML, have higher-risk MDS, with myeloblast count ≥ 20% and acquired/expanded abnormalities inTP53,RUNX1, orRASgenes [19]. Phenotypically, high-grade MD...
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene. 2013;32:663–9. Article CAS Google Scholar Greenberg MV, Bourc’his D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019;20:...
(or even age-related) sites, the changes observed, even in relatively homogeneous cell populations, are not cell autonomous but rather cell population based. That is, they are occurring only in a subset of cells in a tissue. Single-cell data may bring answers to these questions, as well ...
These observations in real signaling systems raise fascinating questions about how distinct input information is encoded into different dynamic patterns of the signaling molecule and the design principles for such networks with multiple signal-encoding functions. Instead of considering the complex molecular ...
However, the biological function and mechanism of CedA remain unknown, which prompted us to address these questions using a combination of quantitative proteomics, cryo-EM, next-generation sequencing (NGS) and biochemical approaches. Results CedA binds RNAP holoenzyme in vivo...
The accuracy of AF2 has been independently evaluated in blind assessments. Yet many questions remain regarding the extent to which these approaches extend our coverage of structural biology, and the limitations of the AF2 method or structures derived from AF2 for applications in biology. Regarding cov...
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Nat Struct Biol 2001, 8:271-279. 32. Huang CC, Smith CV, Glickman MS, Jacobs JWR, Sacchettini JC: Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem 2002, 277:11559-11569. 33. Takahashi M, Terada Y, Nakai I, Nakanishi H, Yoshimura E...