Risk behaviours like alcohol use, smoking and physical inactivity are often first engaged in adolescence and persist into adulthood1Adolescence is a crucial formative period for an individual’s future well-being; the choices made during this period can have important repercussions later in life2For ...
It has been implicated in the regulation of several cellular processes, including transport mechanisms, signal transmission and immune responses. Y-Box-binding protein 1 A transcription factor shown to have a role in oncogenic cell transformation, multidrug resistance and the dissemination of tumours. ...
Due to their sedentary lifestyle, plants have to cope with constantly changing environmental conditions and also have to defend themselves against many biotic aggressors that threaten their development and reproduction. The response to various biotic stresses largely depends on the ability of the plant ...
execute(problem=p1, termination=term, n_trials=5, n_jobs=4, mode="thread", n_workers=4, verbose=True) ## Solve this problem 5 times (n_trials) using 5 processes (n_jobs), each process will handle 1 trial. ## The mode to run the solver is thread (mode), distributed to 4 ...
These processes could act alone or in combination, and they do not necessarily imply changes in overall chromosome morphology [31, 34]. The great degree of 5S repeat dispersion seen in sections Cochlopetalum, Paphiopedilum, Coryopedilum and Pardalopetalum has, to our knowledge, only been ...
As is the case with most autoimmune diseases, one must consider the processes in both the immune response and the target organ. With regard to the immune response, MS has long been considered to be mediated by myelin protein-specific CD4+ T lymphocytes secreting T helper 1 (Th1) type cytoki...
Locomotion accounts for a significant proportion of the energy budget in birds, and selection is likely to act on its economy, particularly where energy co
Here, we review the current landscape of targeted protein degradation approaches and how they have parallels in biological processes. We also outline the ongoing clinical exploration of novel degraders and provide some perspectives on the directions the field might take. This is a preview of ...
Traditional views of cellular metabolism imply that it is passively adapted to meet the demands of the cell. It is becoming increasingly clear, however, that metabolites do more than simply supply the substrates for biological processes; they also provid
Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotr