Full size image The shaft cell and expression of spi/EGF in the bristle are required for F-Cell specification (Fig. 3c,d and Extended Data Fig. 4). We therefore hypothesized that the shaft cell can act as the source of Spi/EGF. We directly tested this hypothesis by silencing spi/EGF ...
From the molecular and cellular points of view, the present elucidation of the mechanisms that maintain cervical epithelial junctions provides an important conceptual advance. It suggests that homeostasis at these sites is not maintained by the transdifferentiation of one epithelial cell type to another....
Another important point of divergence between the two sister species relates to differences in regulating chromatin–NE interactions during mitosis, with unexpected links to nucleolar dynamics. We have shown that although chromosomes must detach from the NE for the duration of mitosis in organisms with ...
Interestingly, the HA- Iporin ∆C853 mutant, which lacks the C-terminus was highly enriched in the cytosolic fraction, indicating that parts of the C-terminus play an important role in the cel- lular localization of Iporin (Figure 5Ab). To address the question, whether the overexpression ...
They are intended to provide a bridge between letters to the editor, research papers and full scientific reviews. The format can be any form that best suits the topic, conveys the key points effectively and encourages insightful and creative thinking. They can be any length but should be ...
3d). It is important to highlight that, for multi-slice spot resolution transcriptomic data, Cell2location should be applied to the entire multi-slice dataset using the same single-cell reference to ensure consistent spot deconvolution results. Calculating SPatially Adjacent Cell type Embedding SpaDo...
We think it is important to note that the specimen was acquired by the Senckenberg Museum to prevent its sale into private hands and to ensure its availability for scientific study [6]. The specimen is currently inventoried as SMF R 4970 in the museum’s collection and remains available to ...
It should emphasize new and important aspects of the study or observations. Graphical abstract A graphical abstract is mandatory for this journal. It should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors ...
It is important for humans to know and understand the diversity of these marine lineages, with all of their bizarre body plans and adaptations, in order to understand how life evolved and how we fit into it. Of more immediate urgency, marine organisms provide a critical source of protein for...
[9, 10]. The recognition of the functions of therapeutic peptides is important. The data-driven computational methods have been widely used in therapeutic peptide function prediction over the past decade. Those methods can be categorized into two groups in terms of the methodologies: (i) binary...