libraries for deep sequencing and W.X. and Y.-N.L. performed bioinformatics analyses, supervised by L.Y.; H.M., X.H., C.C and Y.Z. provided support with techniques. J.C., L.Y., H.Y. and B.Y. wrote the paper with input from the other authors. J.C. managed the project....
Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of Intelligent Biological Medicine (http://www.ISIBM.org), International Journal of Computational...
Material scientists savvy to this have ensured biomimicry is now high on the agenda at research institutions, and an exhibit currently on at the Space Foundation EDF in Paris is doing its best to popularize the notion that we should not just be salvaging the natural world but also learning fro...
into a genome- and phenome-wide association summary statistic matrixWof sizeN × M, whereNandMdenote the number of phenotypes and variants, respectively.NandMwere 2,138 and 235,907 for the “all” variant group; 2,064 and 16,135 for the “coding” variant group; and 628 and 784 fo...
2), which serves as the foundation for multi-slice spatial domain analysis. Fig. 2 SpaDo outperforms existing single-slice spatial domain detection methods. a Performance of SpaDo and other methods (Scanpy, Seurat v4, SEDR, SpaGCN, and STAGATE) on three single-cell spatial transcriptomic ...
Foundation Models Foundation models are large deep learning architectures, such as the transformer-based GPT models by OpenAI, that encode a vast amount of knowledge from diverse sources. Researchers and practitioners can fine-tune these pre-trained models for specific tasks, resulting in high-performa...
The foundation model can be further finetuned on a subset of genomes ("evolutionary finetuning"), in the case of this paper 1.5 million sequences SARS-CoV-2 genomes, yielding a SARS-CoV-2 specific language model, which contains implicit knowledge of the virus' evolutionary landscape and can...
foundation of the field of honeybee behavior, and continue to be cited today. We provide clear evidence that several of these papers contained erroneous information, and many of them contain duplicated and manipulated data. Importantly, the report became a critique not of a single paper, but of...
patterns are likely to emerge. The computational nature of these models makes it easy to analyse very small effects and thus provides an empirical foundation for theoretical analyses that otherwise have to make many non testable assumptions. It will be interesting to see how much of the independent...
To assess the current work and future promise of the biology-materials science intersection, the Department of Energy and the National Science Foundation asked the NRC to identify the most compelling questions and opportunities at this interface, suggest strategies to address them, and consider ...