Importantly, we found that ATAC-seq peaks in patient breast tumours that are occupied by both ER and MAF in MCF7 cells are functionally connected to control of the E2 target gene expression through promoter–enhancer connections, to a higher degree than expected by chance (for example, SOX9 ...
chaos, and information. It boldly explores some of the major questions that consume both philosophers and scientists, such as: how life came to be, what life’s purpose is (to the degree it has one,) what consciousness is and does, and how come we live in a ...
2c,d). The progression and degree of chromosome clustering were thus similar in porcine and human oocytes, although the overall speed of the chromosomes was slightly higher in porcine oocytes, particularly during the second slower phase of chromosome clustering. Actin and microtubules drive chromosome...
Cacao pod color is determined by the degree of red pigment that is superimposed over the base green color of the pod during development. The green color itself ranges widely, from light to dark green [7]. Because the intensity of pod pigment is influenced by the status of the base green ...
because genome centers and sequencing programs proved unwilling to sequence an organism that didn’t already have a large community of researchers studying it. In the end, we took a DIY approach, sequencing and assembling the genome in our own lab in collaboration with the DeRisi lab at UCSF,...
For Golden Retrievers, 20 CNVs were present in all dogs, and for Irish Wolfhounds, 38 CNVs appeared fixed, possibly reflecting the slightly higher degree of inbreeding in Irish Wolfhounds. A much smaller number of breed-specific loci were identified, and no cases of breed-specific fixed CNVs ...
There is general agreement amongst biologists about the need for good pathway diagrams and a need to formalize the way biological pathways are depicted. However, implementing and agreeing how best to do this is currently the subject of some debate. The m
The howler monkey, unlike the rest of its cohort, had a degree of OR gene deterioration similar to the apes and OWMs. The two groups had one other thing in common: full trichromatic vision. Nearly all other placental mammals, including the NWMs, are dichromats, or in common parlance, ...
The length and sequence composition of TRs can influence the degree of epigenetic regulation. Methylation of TRs, for example, can lead to the formation of repressive chromatin and transcriptional silencing. These epigenetic modifications can have a profound impact on gene expression patterns and ...
However, restoration of RING1B mutant variants affected SS18-SSX localization in a manner directly proportional to the degree to which these RING1B mutations impacted H2AK119Ub deposition. Significantly for this study, RING1A ligase-deficient R91E and I53A/D56K were able to form polycomb foci...