Venter and his team have previously accomplished both feats – creating a synthetic genome and transplanting a genome from one bacterium into another –but this time they have combined the two. “It’s the first self-replicating cell on the planet that’s parent is a computer,” says Venter,...
Combined transcriptomics and metabolomics analysis of the flavonoid synthesis pathway In this study, DEGs and DAMs significantly related to flavonoid synthesis were identified. The subsequent analysis of these DEGs and DAMs confirmed that 105 DEGs and 70 related metabolites were associated with flavonoid ...
BgDL model predicts response to anti-PD-1 immunotherapy Fig. 8: Performance of the deep learning model in predicting response and outcomes in patients treated with anti-PD-1 immunotherapy. Full size image Combined Positive Score (CPS) of PD-L1 expression, which is an approved biomarker of immun...
In the sensitivity test of SpaDo combined with spot deconvolution methods, we benchmarked Cell2location against RCTD and SPOTlight. For Cell2location, the single-cell regression model was trained with default parameters and the Cell2location model was obtained with parameter detection_alpha = 20...
A key question in microbial ecology is what the driving forces behind the persistence of large biodiversity in natural environments are. We studied a microbial community with more than 100 different types of species which evolved in a 15-years old biorea
If molecular and population models are combined at a very high level, one can envision the formulation of entirely new mechanistic evolutionary hypotheses. The central role of calibrated computational systems biology models in this approach extends the applicability of this framework beyond that of the...
Roughly a dozen sequence-to-function datasets already exist (see Supplemental Table 1 in this 2022 study), each with more than five thousand data points. But even if all these datasets were combined, they still wouldn’t have anywhere near enough data to build a cursory predictive model. Al...
Starch is stored in higher plants as granules composed of semi-crystalline amylopectin and amorphous amylose. Starch granules provide energy for the plant during dark periods and for germination of seeds and tubers. Dietary starch is also a highly glycem
Except for epithelial cell lines, other mammalian cells including macrophages, neurons cell, mast cells, and B lymphocytes can also be exploited for biosensor applications. Based on the pattern of signal detection and test objective, a specific assay combined with proper cell lines can be used to...
we have combined a large-scale experimental system with a new conceptual framework to establish the strong prevalence and importance of higher-order interactions and to identify patterns of these interactions that should help to circumvent combinatorial complexity as well as to inform effective design of...