The Cdc48 enzyme is an abundant and essential enzyme that functions in many cellular pathways as a protein unfoldase. Here, the authors determine an ensemble of Cdc48 structures that capture snapshots of its unfolding action using a ‘hand-over-hand’ mechanism. Ian Cooney Heidi L. Schubert Pe...
Nature Structural & Molecular Biology(NSMB) has covered an enormous breadth of subjects in the broad field of molecular and structural biology. Here, some of the journal’s past and present editors recount their editorial experience at NSMB and some of the more memorable papers they worked on....
In the past few years, interest in the biology of lipid droplets has increased rapidly (11); the lipid droplet is now recognized as a dynamic organelle with a distinct lipid and protein composition and important functions in the maintenance of cellular lipid homeostasis, energy storage, and the...
Mechanisms of breakpoint origination remain a mystery, but the idea of genes playing the role of “solid” regions can be explained by the fact that their functionality, if lost, may result in the death of the cell, and thus a cell whose genomes have such “broken” genes would most like...
proven effective for simpler organisms, and when the steady-state assumption is valid. However, there are many situations where these conditions do not apply, many of which are biophysically meaningful, such as the dynamic diauxic shift inE. coli....
Discover a wide range of free Biology Essay essay samples. From unique ideas to expertly written papers ➔ find everything you need to excel in your Biology Essay assignments.
as an “aha” moment for both scientists. Peters took the “aha” idea and turned it into the discipline of conservation in the face of climate change. A great poker and street hockey player, Peters was no stranger to getting to the spot before others. His papers with various coauthors ...
Even in static EM images these spiraling rows of fenestrae give the impres- sion of a dynamic process, in which the newly formed fe- nestrae ebb away in the surrounding fenestrated cytoplasm as a tornado. This assumption was confirmed by quantifying the number of fenestrae rows connected to ...
Deep learning algorithms trained to predict masked words from large amount of text have recently been shown to generate activations similar to those of the human brain. However, what drives this similarity remains currently unknown. Here, we systematical
The hijacking of early developmental programs is a canonical feature of gliomas where neoplastic cells resemble neurodevelopmental lineages and possess mechanisms of stem cell resilience. Given these parallels, uncovering how and when in developmental ti