The generation of complex, multicellular organisms of infinite form, originating from a single cell is a fascinating and remarkably dynamic biological process. Developmental anatomy or developmental biology affords an understanding of the properties of individual cells, their organization into tissues, ...
The Cdc48 enzyme is an abundant and essential enzyme that functions in many cellular pathways as a protein unfoldase. Here, the authors determine an ensemble of Cdc48 structures that capture snapshots of its unfolding action using a ‘hand-over-hand’ mechanism. Ian Cooney Heidi L. Schubert Pe...
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Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods ...
In fact, at least 10% of the papers in Cell in the past 15 years have rested on this fact, and the inventors of the sequence comparison algorithms FASTA (Pearson and Lipman 1988) and BLAST (Altschul et al. 1990) may thus arguably share credit with the cited authors for many biological...
Transposable elements (TEs) were first discovered more than 50 years ago, but were totally ignored for a long time. Over the last few decades they have gradually attracted increasing interest from research scientists. Initially they were viewed as totall
In the past few years, interest in the biology of lipid droplets has increased rapidly (11); the lipid droplet is now recognized as a dynamic organelle with a distinct lipid and protein composition and important functions in the maintenance of cellular lipid homeostasis, energy storage, and the...
There is a broad interdisciplinary trend towards considering complex systems as networks of interacting dynamic components in different research areas, including Systems Biology (see e.g. [68]). This new view on complex systems has lead to a variety of new methods and concepts. In Systems Biology...
In the digital era, new socially shared realities and norms emerge rapidly, whether they are beneficial or harmful to our societies. Although these are emerging properties from dynamic interaction, most research has centered on static situations where is
electrotactic ‘SCHEEPDOG’ system which is able to precisely steer collectives of keratinocytes using patterned dynamic electric fields200that distinguish between collective and individual cell behaviors. In addition to technologies, important additions are conceptual tools, such as the active inference ...