Often, addiction to illicit drugs accompanies other types of mental illness such as depression, bipolar ddoi:10.1007/978-1-60327-455-5_48Scott J. RussoColleen A. McClungHumana PressChao J, Nestler E. Molecular neuro- biology of drug addiction. Annu Rev Med 2004; 55:113-32....
Recent research into the biologic basis of drug addiction continues to offer considerable promise for understanding how neurochemistry, pharmacology, and molecular biology relate to the reinforcing effects of abused drugs. One area of research is the development and pharmacologic and neurochemical characteri...
The onset of addiction is marked with drug induced positive experiences that keep being repeated. During that time, adaptation occurs and addiction is stabilized. Interruption of those processes induces polysymptomatic withdrawal syndromes. Abstinence is accompanied by risks of relapse. These features of...
Cigarette smoking is a major heritable risk factor for human diseases. The availability of large datasets has enabled a breakthrough in the genetics of smoking addiction, with >400 loci discovered to date1. Although some of these associations point to genes and pathways of known biological importan...
Drug Addiction The Synapse and Drug Addiction Understanding drug addiction is a matter of understanding how nerves talk to one another. Nerve cells, called neurons, coounicate with electrical impulses called nerve impulses. A nerve impulse travels out from the nerve cell along a long extension ...
2421-ASBMB Methamphetamine and Gene Expression and Plasticity 2246-ASBMB Methods 2255-ASBMB Microarrays 2422-ASBMB MicroRNAs and Drug Addiction 2170-ASBMB Mitochondria in Health and Disease 2151-ASBMB Mitochondria in Signal Transduction Pathways 2152-ASBMB Mitochondrial (Dys)Function and Disease ...
Post-Translational Modification Biology of Glutamate Receptors and Drug Addiction Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, includin... LM Mao,ML Guo,DZ Jin,... - 《Frontiers in Neuroanatomy》 被引...
Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats. Club drug abuse is a growing problem in the United States. Beyond addiction and toxicity are endocrine effects which are not well characterized. Specifical... FH Kobe...
& Neri, S. Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment. Adv. Drug Delivery Rev. 99, 186–196 (2015). Google Scholar Bronzert, D. A. et al. Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines...
We recapitulate well-known gene-context interactions such as oncogene-mutation, paralog buffering, and tissue-specific essential genes, show how mutation rewires known signal transduction pathways, including RAS/RAF and IGF1R-PIK3CA, and illustrate the implications for drug targeting. We further ...