Through research in animal models and humans, Klein and others have shown how and why male and female immune systems respond differently to the flu virus, HIV, and certain cancer therapies, and why most women receive greater protection from vaccines but are also more likely to get severe asthm...
Female and male asthma patients over 18 years of age were enrolled at four sites across the country. Severe asthma diagnosis had to be in agreement with the American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Patients provided patient-reported outcomes on asth...
In particular, male infants delivered from women, which had pre-natal asthma, showed decreased Lactobacilli levels at 3–4 months of age as compared to infants with non-asthmatic mothers. Among infants delivered from asthmatic mothers, male babies also showed reduced Lactobacilli as compared to ...
Of the 72 participants, 37 (51%) were male and 35 (49%) were female. The average age was similar between men (48.7 years, range 23–79) and women (46.0 years, range 20–85). There were no significant gender differences in comorbidities such as hypertension, hypercholesterolemia, obesity,...
aHUS, atypical haemolytic uraemic syndrome; ECU, eculizumab; F, female; KT, kidney transplantation; M, male; MenACWY, meningococcal (serogroups A, C, W-135 and Y) conjugate vaccine; MenB, meningococcal serogroup B vaccine; MenC, meningococcal serogroup C vaccine; Meb-4ps, meningococcal tetravale...
B Immunohistochemical imaging of female and male human amniotic stem cells (hAMSCs) demonstrated a significant increase in QD uptake in female vs male cells. The scale bar represents 50 μm in all panels. (C) QD uptake was quantified using confocal images (n = 7/group). Reproduced ...
To analyse the karyotype of the AM-, CP-, DP- and UC-derived MSCs from the same placenta (male new-born), cell division was blocked at metaphase with 0.1 μg/mL colcemid (Calbiochem, Germany) for 2 hours at 37 °C. The cells were washed and trypsinized, resuspended in 0....
Four key factors contribute to the women’s health gap: limited understanding of sex-based biological differences, healthcare systems designed around male physiology, incomplete data that underestimates women’s disease burden, and chronic underfunding of female-focused research. For instance, despite wom...
(and biomedical research in general) were performed exclusively or predominantly with male research participants. This has led to an incomplete understanding of the pulmonary response to exercise. More recently, important sex-based differences with respect to the human respiratory system have been ...
Jin H, Yan M, Pan C, Liu Z, Sha X, Jiang, C, … Ding J (2022a) Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway. Particle and Fibre Toxicology, 19(1): 13.https://doi.org/...