On 3 May, the European Comission published the "Guideline on the requirements for quality documentation concerning biological investigational medicinal products in clinical trials". The guideline is related to proteins and polypeptides, their derivatives and products of which they are components and addre...
This document is intended to assist investigators and sponsors of studies that evaluate medicinal products in neonates. Since terminology for drugs, medicines, and medicinal products varies around the world, we have simplified these distinctions by using the term medicinal product throughout this document...
licensing requirements, and are used either for prevention, treatment, or diagnosis of disease in humans or animals, or for development,experimental or investigationalpurposes related thereto. They include, but arenot limitedto, finished or unfinished products such as vaccines anddiagnostic products...
Here we attempt to optimize stilbene 5c using computer-based drug design and synthesize derivatives with benzimidazole or indole group. Biological evaluation ... DE Durrant,J Richards,A Tripathi,... - 《Investigational New Drugs》 被引量: 16发表: 2009年 加载更多来源...
Xu, Z.-Q. & Flavin, M. T. & Flavin, J. Combating multidrug-resistant Gram-negative bacterial infections.Expert opinion on investigational drugs23, 163–182 (2014). ArticleCASPubMedGoogle Scholar Control, C. f. D. & Prevention.Antibiotic resistance threats in the United States, 2013. (Cent...
Journal of Medicinal Chemistry, vol. 38, No. 16, Aug. 4, 1995, pp. 3163-3173. Weiner, et al., "A phase I trial of topically applied trans -retinoic acid in cervical dysplasia-clinical efficacy", Investigational New Drugs, 4:241-244, 1996. Jones, et al., "A dose-response study...
TLC. After completion of the reaction, the organic layer was evaporated. The crude product was purified on silica gel column (mesh 100–200) using DCM: MeOH gradient (100: 0 to 70: 30 ratio of DCM: MeOH) mobile phase. The desired products13a-13akwere isolated in moderate to good ...
It was only FDA approved for treating glabellar lines in July of 2011. Approval was based on the results of two crucial U.S. clinical trials involving 547 healthy adult patients and 16 investigational sites. Both trials yielded successful results, with Xeomin significantly improving the appearance ...
V. Leroy et al., Expert Opinion on Investigational Drugs 9(4), 735-746 (2000), and C. Swain et al., Annual Reports in Medicinal Chemistry 34, 51-60 (1999) describe the state of development relating to neurokinin receptor antagonists, while, for example, R. M. Navari et al., Cancer...
Therefore, moxifloxacin, gatifloxacin, levofloxacin, and the investigational drug gemifloxacin have excellent activity against Legionella, Chlamydia, Mycoplasma, and Ureaplasma species [142]. Intracellular respiratory pathogens such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila are ...