Iron-sulfur clusters - reactivities - functions - cluster interconversions - metalloenzymesIron-sulfur clusters are prevalent in biological systems. Through studies of iron-sulfur proteins and synthetic model clusters, it was realized early on that these clusters functioned as facile electron transfer ...
Iron sulfur (Fe-S) proteins are found in a variety of organisms. They usually function in electron transport, but they may also be involved in other functions like gene regulation and Lewis acid catalysis. The structure and spectroscopic properties of Fe-S clusters holding one, two, three, or...
One particular non-classical function of these iron chelators, namely antibiotic activity, was documented before the role of siderophores in iron transport was established. In this Perspective, we present an exposition of past and current work into non-classical functions of siderophores and highlight...
It functions as a protein cofactor in fundamental pathways including respiration, photosynthesis and the biogeochemical cycling of sulfur and nitrogen. There are two major types of iron-containing protein cofactors, haemes and iron–sulfur clusters. The most common iron–sulfur cluster is the cubane-...
Transferrin not only acts as a transport agent but also functions as an iron buffer, maintaining free ferric ion concentrations in the body at a very low but constant value. This role of transferrin, and our understanding of the mechanisms of iron binding and release by the protein, are ...
TETs functions and binding partners The primary functions of TETs are able to oxidate 5mC, and the products are subsequently involved in DNA demethylation.64,65,66Besides, TET genes expression in different tissues are analyzed using the proteinatlas database67(https://www.proteinatlas.org/) in ...
(+)-Nicotianamine and its naturally occurring antipode exhibited the same biological activity with regard to chlorophyll formation of chlorotic leaflets of the mutant chloronerva. It is therefore concluded that nicotianamine does not exert its functions by a stereospecific binding to a macromolecular surf...
The pluripotent gaseous messenger molecule nitric oxide (NO) controls vital functions such as neurotransmission or vascular tone (via activation of soluble guanylyl cyclase), gene transcription, mRNA translation (via iron-responsive elements), and post-translational modifications of proteins (via ADP-ribos...
Such functions allow for a proper characterization of the stochastic energy deposition by radiation at the cellular and sub-cellular scale of interest, without increasing the computational time. In particular, the frequency f(y) and dose distribution d(y) of the lineal energy y are used. The ...
An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder. Molecular Psychiatry. 2020:1-2. Lovelace MD, Varney B, Sundaram G, Lennon MJ, Lim CK, Jacobs K, et al. Recent evidence for an expanded role of the kynurenine pathway of tryptophan...