HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus. John A. Tadross ,Lukas Steuernagel &Giles S. H. Yeo Article|05 February 2025 RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast ...
of Function in the Brain THE ENDOCRINE SYSTEM BRAIN DAMAGE, PLASTICITY, AND REPAIR The Brain's Plasticity and Capacity for Repair w Brain Tissue Implants GENETIC AND EVOLUTIONARY BLUEPRINTS OF BEHAVIOR Chromosomes, Genes, and DNA w The Study of Genetics w Genetics and Evolution Learning Goals 1 ...
The hypothesis of this study is that different prenatal nutritional strategies have long-term effects impacting the liver tissue transcriptome-metabolome through changes in biological pathways. The objectives of the present study were threefold: (1) To evaluate whether the different prenatal nutritional st...
Agent-based models (ABMs)—also called individual-based models (IBMs)—for cellular systems are a class of computer models that aim to simulate multicellular dynamics, identifying the behavior of every individual cell and capturing natural spatial in homogeneities and variability be...
Diagrams in right-bottom part created for all extensions, show changes in behavior of GDDA in relation to net size (Data used for diagrams can be found in Tables S4–S9 from Supplementary Material). Heatmaps in right-top part show distance in GDDA values between each pair tested extensions20...
Previously, cell viscoelastic properties were obtained by fitting the mechanical behavior measured via quasi-static or oscillatory AFM force curves to a standard linear solid (SLS) or a PLR model, for which the response of the specimen must follow a specific monotonic trend as defined by the ...
Partitions are sampled after the algorithm has passed through all four stages several times (default = 5). Passing through the stages generates partitions that are largely independent of each other, but there may be some historical influence. Therefore, the default behavior is to gather solutio...
of consciousness both within and across species (see also Veit and Browning (forthcoming b)). Nevertheless, the evolution of consciousness—similar to the evolution of behavior—gives rise to a new adaptive domain in which a pathological mismatch can arise between the evaluations of an organism ...
Several other examples of rules and the corresponding paths that could be generated from the graph are shown in Fig.1b. They all show the therapeutic basis of how a drug is connected to the disease. A limitation of this approach is the vast amount of evidence chains that can be generated...
Design inspiration comes from the continuous stimulation of external information and the continuous accumulation of knowledge. In order to obtain an ideal design inspiration from nature, researchers have proposed a large number of biological information