Unfortunately, existing treatments for AD aim to decrease cutaneous inflammation, but are not specific for the pathways driving this disease. An increasing understanding of the immune mechanisms underlying AD brings the promise of narrow targeted therapies as has occurred for psoriasis, another ...
Across both programs, four Phase 3 trials are ongoing and designed to inform next-generation treatments for people with COPD who might not have other options. Itepekimab is currently under clinical investigation and its safety and efficacy have not been evaluated by any regulat...
The signals we have detected will be examined for validity using the same robust analytical pipeline in PSORT, which we show is substantially powered to detect true biomarkers of response to therapy. Likewise, as omics techniques are applied to other dermatological diseases such as atopic eczema (...
especially for elderly patients. There is a significant unmet medical need for new medicines for people suffering with this hard-to-treat disease in which the standard of care is oral and topical corticosteroids and immunosuppressants – treatments that have poor clinical outcomes and ...
Sullivan R, Preda V. Treatments for severe psoriasis.Australian Prescriber.2009; 32: 14-18. [Full Text] Magin P, Adams J, Heading G, et al. Patients with skin disease and their relationships with their doctors: a qualitative study of patients with acne, psoriasis and eczema.Medical Journal...
Biologics targeting the tumour necrosis factor (TNF) and interleukin (IL)-17/23 axis are effective treatments for psoriasis but can result in cutaneous adverse events. The pathogenesis of paradoxical eczema, a phenotype resembling atopic eczema occurring after biologic initiation for psoriasis, is ...
A growing number of treatment options are becoming available for moderate-to-severe atopic dermatitis (AD), including biologic therapies. As these treatments have different efficacy, safety, and tolerability profiles, it is important to understand patient and physician preferences for informed treatment ...