The integrity of the skeleton is maintained by continuous remodeling of bone tissues throughout life in response to a broad spectrum of physiologic signals. As described in Chapter 9, the active hormone 1,25-dihydroxyvitamin D 3 (vitamin D) plays a key role in the maintenance of calcium and ...
hydroxyvitamin D3 cystinosis nutritional rickets 1,25-dihydroxyvitamin D, pseudodeficiency rickets Hereditary hypophosphatemia 1,25-Dihydroxyvitamin D, and 1,~-HydroxyvitaminD, in Children: Biologic and Therapeutic Effects in ~ u t r i t i o n aRi ickets and Different Types of Vitamin D ...
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61and blocking its signaling in progenitors impedes T-cell development, instead favoring the B-cell lineage.62,63A role forNOTCH1in T-ALL was first suspected because of a rare translocation, t(7;9)(q34;q34.3). This rearrangement coupled theTCRβlocus...
63A role forNOTCH1in T-ALL was first suspected because of a rare translocation, t(7;9)(q34;q34.3). This rearrangement coupled theTCRβlocus to ICN1, the IntraCellular portion of NOTCH1, a constitutively active form of the protein.64NOTCH1's role was further substantiated by animal models...
Traditional treatments for the management of mild-to-moderate psoriasis have included topical treatments such as corticosteroids, dithranol (anthralin derivative), coal tar and vitamin D3analogues, as well as phototherapy (Ahmeen, M. (2003)Pharmacogenomics4:297-308). More severe disease requires sys...
(herein, cofactors) include without limitation substances that promote tissue repair and regeneration and/or inhibit inflammation. Examples of useful cofactors for stimulating bone tissue growth in osteoporotic individuals, for example, include but are not limited to, vitamin D3, calcitonin, ...
The hormonally active form of vitamin D is 1,25(OH)2-vitamin D3 [1,25(OH)2D3]. This seco-steroid is the key mediator of the vitamin D endocrine system which produces biological effects in over 28 target tissues. In these target tissues, the biological responses may be generated both ...
Vitamin D 3 is hydroxylated in the liver at C-25 to form 25-hydroxyvitamin D 3 [25(OH)D 3 ], followed by hydroxylation at the C-lin kidneys to form 1,25dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], the active form of vitamin D. However, further exposure to sunlight can photoiso...
Bioavailable vitamin D (not bound to DBP) is thought to be more biologically active in target tissues.Elvan BayramoluGülen AkkoAye Abazlem AkgünKamer YurdakulHatice Nilgün Seluk DuruMurat ElevliDepartment of Pediatric Endocrinology University of Health Sciences Haseki Training and ResearchEuropean ...