PLK2was consistently downregulated in GBM tissues. Overexpression ofPLK2in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting thatPLK2overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression...
Gene Y, on the other hand, shows low expression in all tissues except for the lung, where it is highly expressed.” Thereby ChatGPT, at its simplest level, could be used to ask general questions like “What is the function of gene product X?” an...
A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical and cadaveric approaches, in which light stimuli were applied to the head and/or neck. PubM
Second, peroral dosing of PABA showed complete retrieval in urine within 24 h (94.75 ± 3.54%, cf. sectionPABA metabolism after oral and intradermal administration). Since PABA is fully dissolved in the tattoo ink, it can be assumed that it is freely available in the body, as was ...
Cancer cells with > 100 units of activity are hypersensitive to ß-lap, while normal tissues that lack, or express low levels of, NQO1 are spared13. We previously demonstrated that a lethal dose of ß-lap (~4 μ M) creates a significant level of DNA lesions in NQO1-expressing...
Retinal degenerationis a main class ofocular diseases, which is mainly caused by the loss and death of retinal neuronal cells, leading to a decline in visual function or evenblindness[1]. So far, transplantation of retinalprogenitor cells(RPCs) has been one of the most potential therapy for ...
'Laboratory diagnosis' includes those methods used to confirm the clinical observations of a physician by evaluation of standard clinical specimens, such as blood, serum, exudates, saliva, stool and tissues (TABLE 9). The necessity for the rapid detection of BSAT-related illness and intervention ...
viral (AAV) vectors as they have an excellent safety profile and can mediate long-term transgene expres- sion from postmitotic tissues such as the liver [40–42]. Indeed, our ongoing gene therapy clinical trial for hae- mophilia B, a related bleeding disorder, has demon- strated that a ...
Advanced tools for biomedicine are possible using concepts similar to those of Figure 4d, but with multiple sensing and electronic modalities, and the capacity to laminate onto soft, moist curvilinear tissues with robust adhesion, waterproof construction and without any significant effects of mass ...
04 August 2016 accepted: 29 November 2016 Published: 05 January 2017 Sonia R. Salvatore1, Dario A. Vitturi1, Marco Fazzari1,2, Diane K. Jorkasky3 & Francisco J. Schopfer1 Nitrated fatty acids are endogenously present in human and animal tissues, as well as in plant...