Some of these proteins, such as LDL, can be enriched from blood into tumor cells compared to normal tissues21. Other studies have shown positive or negative correlations between PpIX accu- mulation and peptide transporter 1 (PEPT1)12 or ATP-binding cassette sub-family G member 2 (ABCG2)12...
In contrast to DJ-1 deficient BMM challenged with lipopolysaccharide, DJ-1 deficient BMM exposed to intact bacteria showed enhanced Rubicon complexing with Beclin-1 and UVRAG and consistently facilitated the assembly of complete autophagolysosomes that were decorated with LC3 molecules. Our data shows ...
No abstract is available for this article.doi:10.1002/scin.5591840117EhrenbergRachelJohn Wiley & Sons, Ltd.Science News
17. A composition according to claim 16 wherein the substance that binds to the peripheral benzodiazepine receptor is a peripheral benzodiazepine receptor agonist chosen from synthetic molecules, natural extraction substances and substances obtained by fermentation. 18. A composition according to claim 17...
RXRα has been shown to bind small molecules with diverse structures.15,17 Recent studies have revealed the existence of small-molecule-binding sites distinct from the classical LBP.38,39,50 Crystal structure studies showed that begelovin, a RXRα agonist lacking the carboxylate moiety, binds to...
MT1-MMP interactions with membranes could possibly couple with modes of its dimerization and association with other cell surface molecules. Careful appraisal of the proximity of MT1-MMP to lipid bilayers is warranted by its relevance to the digestion of collagen, pro-growth factors, and receptors ...
WO2000032773A1 2000-06-08 COMPOSITIONS AND METHODS FOR INCREASING BONE MINERALIZATION WO2001092308A2 2001-12-06 CYSTINE-KNOT POLYPEPTIDES: CLOAKED-2 MOLECULES AND USES THEREOF WO2002024888A2 2002-03-28 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME EP0404097 1990-12-27 Oth...
1990). However, plasminogen knockout mice display none of the pathologic features of TGF β knockout mice, suggesting that plasmin is unlikely to be the only molecule activating TGF β. Reactive oxygen species can activate TGF β in vitro (Barcellos-Hoff and Dix 1996), and radiation treatment...
Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140 and P110, interact to form a Nap complex anchored to the
The endoplasmic reticulum, the cytoplasmic organelle that matures a massive amount of nascent secretory polypeptides, is particularly sensitive to stress. Endoplasmic reticulum stress causes unfolded proteins to populate the organelle, eliciting the unfo