您是否使用电子翻译? [translate] afinding an enzyme inhibitor is the result of a good match of the biological and chemical spaces represented by a binding site of an enzyme and a 发现酶抑制剂是生物和化工空间的一次好比赛的结果酵素和a的束缚位置代表的 [translate] ...
On the contrary, the binding of the pyridine nucleotide substrate is significantly perturbed demonstrating that the C-terminal potential ADP-binding fold of the beta subunit is indeed the NADPH-binding site of the enzyme. The major effect of the G298A substitution in the GltS beta subunit ...
(including 2 adjacent) phosphates. The phosphate of the scissilephosphodiester bondis anchored to theenzymevia the catalytic Ca2+ion. The binding of DNase I to the minor groove is asymmetric, covering but making no contacts with the major groove on the 3′ side of the cleavage site. Regarding...
Biochemistry Site -directed mutagenesis as a probe of NAD+-binding site in malic enzyme THE UNIVERSITY OF OKLAHOMA Paul F. Cook AktasDeniz FulyaThe mitochondrial NAD-malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate and CO. The role of the dinucleotide substrate in oxidative...
The circular dichroism spectra of the mutants were the same as that of the wild-type enzyme. The results from the site-directed mutagenesis demonstrate that the presumed interactions of investigated residues with ATP are important for the stabilization of the transition state. 展开 ...
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Although Rac2 is the specific GTPase for the NADPH oxidase, Rac1 can activate this enzyme complex. The physiologic roles for these proteins are not well defined and it is unclear if the overlapping functions represent a dual dependency or dual requirement. View chapterExplore book Rho GTPases ...
Mapping the NAG5binding site of HEWL Differential footprinting of HEWL by photoactivation of2was performed in the presence and absence of NAG5(see the ‘Methods’ section). Irradiation of the sample following flash freezing had the dual benefit of halting enzyme turn-over and reducing diffusion of...
We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus–receptor interactions by both steric hindrance and direct ...