requires that cooperativity in oxygen binding be attributed primarily to deviations of the successive dissociation velocity constants from their statistical values, and is consistent with the idea that the major change in reactivity occurs after 1 ligand molecule has dissociated from saturated hemoglobin. ...
The phenomenon of cooperativity was initially observed and studied through the allosteric binding of oxygen to hemoglobin over a century ago (1, 2, 3). A classical model of positive cooperativity is described as a multimeric protein, in which the affinity for ligand binding to an open site on...
Herein, we report the preparation of new low-spin six-coordinate [Fe(II)(PPIX)L(CO)] complexes where L is either an aliphatic or aromatic nitrogenous ligand. Some of the aromatic ligands contain two or moreNatoms or another hetero atom in the aromatic ring. To gain further insight into ho...
Oxygen and CO ligand binding kinetics have been studied for the hybrid hemoglobin (Hb) alpha (human):beta (carp), hybrid II. Valency and half-saturated hybrids were used to aid in the assignment of the conformations of both chains. In hy... LJ Parkhurst,DJ Goss - 《Biochemistry》 被引量...
b) CCK c) Transferrin d) Secretin e) Interferon Iron: Iron is a necessary cofactor for many cellular processes, including the transport of oxygen throughout the body. Oxygen can be transported through the body using the protein hemoglobin, which contains iro...
resistance. Indeed, deletion of the malaria mitochondrial protease PfDegP has been reported to reduce heme levels and DHA susceptibility45. Thus, the detection of PfKelch13 proximal to heme/hemoglobin-containing cellular structures (either cytosolic or membrane-bound) and the evidence of a labile ...
Oxygen binding and its allosteric control in hemoglobin of the pulmonate snail, Biomphalaria glabrata. Am J Physiol. 1999. 276(2 Pt 2): R347-356.Bugge, J, Weber, RE (1999) Oxygen binding and its allosteric control in hemoglobin of the pulmonate snail, Biomphalaria glabrata. Am J Physiol ...
Identifying the DNA-binding specificities of transcription factors (TF) is central to understanding gene networks that regulate growth and development. Such knowledge is lacking in oomycetes, a microbial eukaryotic lineage within the stramenopile group.
In 1970, Perutz (1) published a detailed mechanistic interpretation of cooperative oxygen binding to hemoglobin (Hb). Two key structural features of the protein molecule were stressed. First, in deoxy-Hb, the ferrous iron atom was high spin and out of the plane of the porphyrin ring toward ...
Since the landmark structure determination of the first oxygen-binding heme proteins, hemoglobin and myoglobin, an increasing number of other heme proteins that bind gaseous ligands have been characterized. These include, besides members of the widespread vertebrate globin family that transport oxygen, ...