This paper will argue, however, that the Akedah, or 'binding' of Isaac, as Kierkegaard's pseudonym, Johannes de Silentio, depicts it, binds Abraham to Isaac in a revitalized neighbor relation that is not at all subordinate, in any simple way, to Abraham's God-relation. The two relations...
Isaac Rosado-Sánchez, Megan K. Levings, in Cellular Immunology, 2020 3 The Antigen-binding domain The basic CAR structure comprises an antigen-binding domain, a hinge, a transmembrane domain and one or more intracellular signalling domains. The antigen-binding domain is the extracellular part of...
Parth K.ModiMD, ...Isaac YiKimMD, PhD, inProstate Cancer (Second Edition), 2016 DNA-Binding Domain (DBD) The DBD is a highly conserved region that contains 70 amino acids. In the DNA-binding region there are two zinc fingers complexed with four cysteine residues each. This region allows...
PDZ domain, an evolutionarily conserved globular structure composed of 80-90 AAs (amino acids) recognizes particular regions of their interactors [6,11,12]. PDZ domains primarily bind to the C-terminal ends of proteins. Interactions between PDZ domains and internal regions of their binding partners...
Replication stress (RS) is a major source of genomic instability and is intrinsic to cancer cells. RS is also the consequence of chemotherapeutic drugs for treating cancer. However, adaptation to RS is also a mechanism of resistance to chemotherapy. BRCA
We previously identified CLEC14A as a tumour endothelial marker. Here we show that CLEC14A is a regulator of sprouting angiogenesis in vitro and in vivo. Using a human umbilical vein endothelial cell spheroid-sprouting assay, we found CLEC14A to be a reg
Isaac Bishof,…, Nicholas T. Seyfried View PDF RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice Blood, Volume 141, Issue 24, 2023, pp. 2961-2972 Charles Bramlett,…, Rong Lu View PDFShow 3 more articles Article Metrics Citations Citation Indexes: 223 Cap...
NSF Binding to GluR2 Regulates Synaptic Transmission Author links open overlay panelAtsushi Nishimune 1 §, John T.R Isaac 2 §, Elek Molnar 2 ∣∣, Jacques Noel 2, S.Russell Nash 1, Mitsuo Tagaya 3, Graham L Collingridge 2, Shigetada Nakanishi 1, Jeremy M Henley 1 2 #Show more...
PDZ domains are abundant protein interaction modules that often recognize short amino acid motifs at the C-termini of target proteins. They regulate multiple biological processes such as transport, ion channel signaling, and other signal transduction sys