The ligand binding mode is the same in A and B, while the conformation assumed by the residues form- ing the binding cavity, the A-loop and αG-helix is different (SI Fig. S8). In B, the A-loop assumes a more open conformation loosing the contact with motion, leading to the ...
This kind of architecture prevents from loosing fine-grained information about the input which greatly increases the precision of the resulting segmentations. Figure 1 Kalasanty’s architecture. Full size image Kalasanty was built using the same ideas and architecture design as the original U-Net. ...
In this study we targeted a selection of the amino acids that are positioned within the two DI loops by mutagenesis, which revealed that replacement of several residues with a neutral alanine modulated hFcRn binding either by gaining or loosing binding affinity at acidic pH, whereas none of the...
The ligand binding mode is the same in A and B, while the conformation assumed by the residues forming the binding cavity, the A-loop and αG-helix is different (SI Fig. S8). In B, the A-loop assumes a more open conformation loosing the contact with the β3-αC loop. The loss ...